Lysosomal exocytosis in Schwann cells contributes to axon remyelination

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	Lysosomal exocytosis in Schwann cells contributes to axon remyelination
	Chen, Gang ; Zhang, Zhijun ; Wei, Zhongya ; Cheng, Qiong ; Li, Xia ; Li, Wei ; Duan, Shumin ; Gu, Xiaosong
刊名	GLIA
	2012
卷号	60 期号:2 页码:295-305
关键词	schwann cell lysosome exocytosis myelin MYELIN-ASSOCIATED GLYCOPROTEIN RAT PERIPHERAL-NERVE SECRETORY LYSOSOMES MESSENGER-RNA NEURAL CREST PROTEIN RAB27A REGENERATION DISORDERS LINEAGE
ISSN号	0894-1491
通讯作者	Chen, G (reprint author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China,chengang6626@ntu.edu.cn ; neurongu@public.nt.js.cn
英文摘要	Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport, and cytoskeletal dynamics. Although abnormalities of myelin are common in lysosomal storage diseases, our understanding of the role of lysosomes in the formation and maintenance of myelin is still limited. Here, we show that late endosomes/lysosomes in Schwann cells contain abundant myelin protein P0, which accounts for over half the total protein of compact myelin in the peripheral nervous system and exhibit Ca2+-dependent exocytosis in response to various stimuli. Downregulation of Rab27a, a small GTPase required for the trafficking of the secretory lysosomes to the plasma membrane, largely blocked lysosomal exocytosis in Schwann cells and reduced the remyelination of regenerated sciatic nerve. These findings highlight a novel role for lysosomes in Schwann cells and suggest that the regulated lysosome exocytosis in Schwann cells may have important physiological and pathological significance in the peripheral nervous system. (c) 2011 Wiley Periodicals, Inc.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Natural Science Foundation of China[30800315, 81130080, 30800348]; Major State Basic Research Program of China[2011CB504400]; Jiangsu Province Natural Science Foundation of China[BK2009155]; Jiangsu Province Education Commission Natural Science Foundation of China[08KJB180009]; Jiangsu Province Qing Lan Project, Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); New Century Excellent Talents in University[NCET-10-0180]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1507]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Chen, Gang,Zhang, Zhijun,Wei, Zhongya,et al. Lysosomal exocytosis in Schwann cells contributes to axon remyelination[J]. GLIA,2012,60(2):295-305.
APA	Chen, Gang.,Zhang, Zhijun.,Wei, Zhongya.,Cheng, Qiong.,Li, Xia.,...&Gu, Xiaosong.(2012).Lysosomal exocytosis in Schwann cells contributes to axon remyelination.GLIA,60(2),295-305.
MLA	Chen, Gang,et al."Lysosomal exocytosis in Schwann cells contributes to axon remyelination".GLIA 60.2(2012):295-305.