GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses

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	GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses
	Poo, Mu-ming
刊名	NATURE NEUROSCIENCE
	2008
卷号	11 期号:12 页码:1410-1418
关键词	LONG-TERM POTENTIATION INHIBITORY SYNAPTIC-TRANSMISSION HIPPOCAMPAL PYRAMIDAL CELLS NEONATAL-RAT HIPPOCAMPUS VISUAL-CORTEX REBOUND POTENTIATION CORTICAL-NEURONS KINASE-II INDUCTION MECHANISMS
ISSN号	1097-6256
通讯作者	Poo, MM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,mpoo@berkeley.edu ; xhzhang@ion.ac.cn
英文摘要	Activity-induced long-term modification of glutamatergic synapses depends on the frequency of synaptic activation. We found that long-term modification of developing rat hippocampal GABAergic synapses that was induced by repetitive coincident pre- and postsynaptic spiking was also frequency dependent. Spiking at 20-50 Hz resulted in synaptic potentiation, whereas spiking at 5 Hz led to synaptic depression. The potentiation was abolished by blocking GABA(B) receptors (GABA(B)Rs), whereas the depression was independent of GABA(B)R activation and could be converted to potentiation by elevating GABA(B)R activity. The potentiation could be attributed to a local postsynaptic increase in Na(+)/K(+)/2Cl(-) co-transporter activity near activated synapses. The activity of postsynaptic Ca(2+)/calmodulin-dependent protein kinase II was necessary for long-term potentiation of these developing GABAergic synapses and its phosphorylation at Thr286 could be enhanced by activating GABA(B)Rs with baclofen. Together with our finding that activation of GABA(B)Rs is frequency dependent, these results indicate that postsynaptic GABA(B)R activation mediates frequency-dependent potentiation of developing GABAergic synapses.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Basic Research Program of China[2006CB806600, 2006CB943900]; US National Institutes of Health[NS 36999]; International Human Frontier Science Program Career Development Award
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1690]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组
推荐引用方式 GB/T 7714	Poo, Mu-ming. GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses[J]. NATURE NEUROSCIENCE,2008,11(12):1410-1418.
APA	Poo, Mu-ming.(2008).GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses.NATURE NEUROSCIENCE,11(12),1410-1418.
MLA	Poo, Mu-ming."GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses".NATURE NEUROSCIENCE 11.12(2008):1410-1418.