Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex

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	Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex
	Poo, Mu-ming
刊名	JOURNAL OF NEUROSCIENCE
	2010
卷号	30 期号:5 页码:1861-1868
关键词	FREQUENCY-MODULATED SWEEPS PRIMARY VISUAL-CORTEX ECHO-LOCATING BATS INFERIOR COLLICULUS UNDERLYING SELECTIVITY RECEPTIVE-FIELDS SIMPLE CELLS COMMUNICATION SOUNDS STIMULUS SELECTIVITY BALANCED INHIBITION
ISSN号	0270-6474
通讯作者	Dan, Y (reprint author), Univ Calif Berkeley, Dept Cell & Mol Biol, Div Neurobiol, Berkeley, CA 94720 USA,ydan@berkeley.edu ; xhzhang@ion.ac.cn
英文摘要	Frequency modulation (FM) is a prominent feature in animal vocalization and human speech. Although many neurons in the auditory cortex are known to be selective for FM direction, the synaptic mechanisms underlying this selectivity are not well understood. Previous studies of both visual and auditory neurons have suggested two general mechanisms for direction selectivity: (1) differential delays of excitatory inputs across the spatial/spectral receptive field and (2) spatial/spectral offset between excitatory and inhibitory inputs. In this study, we have examined the contributions of both mechanisms to FM direction selectivity in rat primary auditory cortex. The excitatory and inhibitory synaptic inputs to each cortical neuron were measured by in vivo whole-cell recording. The spectrotemporal receptive field of each type of inputs was mapped with random tone pips and compared with direction selectivity of the neuron measured with FM stimuli. We found that both the differential delay of the excitatory input and the spectral offset between excitation and inhibition are positively correlated with direction selectivity of the neuron. Thus, both synaptic mechanisms are likely to contribute to FM direction selectivity in the auditory cortex. Finally, direction selectivity measured from the spiking output is significantly stronger than that based on the subthreshold membrane potentials, indicating that the selectivity is further sharpened by the spike generation mechanism.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	Knowledge Innovation Program of the Chinese Academy of Sciences[KSCX2-YW-R-29]; Major State Basic Research Program of China[2006CB806600]; United States National Institutes of Health
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1618]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组
推荐引用方式 GB/T 7714	Poo, Mu-ming. Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex[J]. JOURNAL OF NEUROSCIENCE,2010,30(5):1861-1868.
APA	Poo, Mu-ming.(2010).Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex.JOURNAL OF NEUROSCIENCE,30(5),1861-1868.
MLA	Poo, Mu-ming."Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex".JOURNAL OF NEUROSCIENCE 30.5(2010):1861-1868.