Transducer of regulated CREB and late phase long-term synaptic potentiation

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	Transducer of regulated CREB and late phase long-term synaptic potentiation
	Xiong, Zhi-Qi
刊名	FEBS JOURNAL
	2007
卷号	274 期号:13 页码:3218-3223
关键词	CREB hippocampus LTP TORCs ELEMENT-BINDING PROTEIN SENSITIVE COINCIDENCE DETECTOR MEDIATED GENE-EXPRESSION COACTIVATOR TORC2 TRANSCRIPTION FACTORS MEMORY HIPPOCAMPUS INDUCTION MECHANISM CALCIUM
ISSN号	1742-464X
通讯作者	Xiong, ZQ (reprint author), Chinese Acad Sci, Lab Neurobiol Dis, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xiongzhiqi@ion.ac.cn
英文摘要	In the central nervous system, long-term adaptive responses to changes in the environment, such as the processes involved in learning and memory, require the conversion of extracellular stimuli into intracellular signals. Many of these signals involve the induction of gene expression. The late, transcription- and translation-dependent phase of long-term synaptic potentiation (L-LTP) is an attractive cellular model for long-lasting memory formation. The transcription factor cAMP response element-binding protein (CREB) plays an essential role in the maintenance of L-LTP. However, how synaptic signals propagate to the nucleus to initiate CREB-target gene expression is unclear. Recent studies indicate that the CREB transducer of regulated CREB activity 1 coactivator undergoes neuronal activity-dependent translocation from the cytoplasm to the nucleus, a process required for CRE-dependent gene expression and the maintenance of L-LTP in the hippocampus.
学科主题	Biochemistry & Molecular Biology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1761]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_疾病神经生物学研究组
推荐引用方式 GB/T 7714	Xiong, Zhi-Qi. Transducer of regulated CREB and late phase long-term synaptic potentiation[J]. FEBS JOURNAL,2007,274(13):3218-3223.
APA	Xiong, Zhi-Qi.(2007).Transducer of regulated CREB and late phase long-term synaptic potentiation.FEBS JOURNAL,274(13),3218-3223.
MLA	Xiong, Zhi-Qi."Transducer of regulated CREB and late phase long-term synaptic potentiation".FEBS JOURNAL 274.13(2007):3218-3223.