Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus

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	Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus
	Xiong, Zhi-Qi
刊名	JOURNAL OF NEUROCHEMISTRY
	2009
卷号	111 期号:5 页码:1094-1103
关键词	global ischemia hippocampus neurodegeneration proteasome ubiquitination TRANSIENT CEREBRAL-ISCHEMIA PROTEIN AGGREGATION CORTICAL-NEURONS CA1 NEURONS MITOCHONDRIAL DYSFUNCTION DEGRADATION SIGNALS FOREBRAIN ISCHEMIA ZINC TOXICITY INDUCED DEATH NITRIC-OXIDE
ISSN号	0022-3042
通讯作者	Xiong, ZQ (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xiongzhiqi@ion.ac.cn
英文摘要	Deposition of ubiquitinated protein aggregates is a hallmark of neurodegeneration in both acute neural injuries, such as stroke, and chronic conditions, such as Parkinson's disease, but the underlying mechanisms are poorly understood. In the present study, we examined the role of Zn2+ in ischemia-induced impairment of the ubiquitin-proteasome system in the CA1 region of rat hippocampus after transient global ischemia. We found that scavenging endogenous Zn2+ reduced ischemia-induced ubiquitin conjugation and free ubiquitin depletion. Furthermore, exposure to zinc chloride increased ubiquitination and inhibited proteasomal enzyme activity in cultured hippocampal neurons in a concentration- and time-dependent manner. Further studies of the underlying mechanisms showed that Zn2+-induced ubiquitination required p38 activation. These findings indicate that alterations in Zn2+ homeostasis impair the protein degradation pathway.
学科主题	Biochemistry & Molecular Biology ; Neurosciences & Neurology
收录类别	SCI
资助信息	National Basic Research Program of China[2006CB806600]; Key State Research Program of China[2006CB943900]; Innovative Research Group of The National Natural Science Foundation of China[30721004]; Chinese Academy of Sciences[KSCX2-YW-R-099]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1627]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_疾病神经生物学研究组
推荐引用方式 GB/T 7714	Xiong, Zhi-Qi. Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus[J]. JOURNAL OF NEUROCHEMISTRY,2009,111(5):1094-1103.
APA	Xiong, Zhi-Qi.(2009).Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus.JOURNAL OF NEUROCHEMISTRY,111(5),1094-1103.
MLA	Xiong, Zhi-Qi."Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus".JOURNAL OF NEUROCHEMISTRY 111.5(2009):1094-1103.