Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons

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	Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons
	Zhang, Xu
刊名	MOLECULAR PAIN
	2010
卷号	6 页码:23-23
关键词	NECROSIS-FACTOR-ALPHA DORSAL-ROOT GANGLION PRIMARY AFFERENT NEURONS CHROMOSOMAL LOCALIZATION NEUROPATHIC PAIN TNF-ALPHA PERIPHERAL INFLAMMATION BOWEL-DISEASE SCIATIC-NERVE GROWTH-FACTOR
ISSN号	1744-8069
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn
英文摘要	Pancreatitis-associated protein (PAP)-I and -II, lectin-related secretory proteins, are members of the regenerating gene (Reg) family. Although expression of PAP-I was found in the dorsal root ganglion (DRG) neurons following peripheral nerve injury and cystitis, whether PAP-II could be expressed in DRG neurons in chronic pain models remains unclear. The present study shows an inflammation-and nerve injury-triggered expression of PAP-II in rat DRG neurons. In situ hybridization showed that only a few DRG neurons normally contained PAP-I and -II mRNAs. After peripheral inflammation, PAP-I and -II mRNAs were present in over half of small DRG neurons. Such an elevated expression of PAPI and -II reached the peak level on the second day. Immunostaining showed that the expression of PAP-II was mostly increased in the isolectin B4-positive subset of small DRG neurons after inflammation. Furthermore, the expression of PAP-II was also induced in DRG neurons after peripheral nerve injury. Interestingly, PAP-II expression was shifted from small neurons on day 2 to large DRG neurons that expressed neuropeptide Y during the later post-injury days. These results suggest that PAP-II may play potential roles in the modulation of spinal sensory pathways in pathological pain states.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	NNSFC[30630029, 30621062]; MOST 973 project[2006CB806604, 2009CB522005]; CAS[KSCX1 YW R 31]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1597]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组
推荐引用方式 GB/T 7714	Zhang, Xu. Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons[J]. MOLECULAR PAIN,2010,6:23-23.
APA	Zhang, Xu.(2010).Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons.MOLECULAR PAIN,6,23-23.
MLA	Zhang, Xu."Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons".MOLECULAR PAIN 6(2010):23-23.