Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal

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	Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal
	Prasenjit Manna ; Manoranjan Ghosh ; Jyotirmoy Ghosh ; Joydeep Das ; Parames C.Sil
刊名	Nanotoxicology
	2011-02
卷号	6 期号:1 页码:1-21
关键词	Nano-copper particles hepatic dysfunction antioxidant defense IκBα/NF-κBMAPKs Bcl-2 family proteins mitochondrial signal and apoptosis of hepatocytes
通讯作者	Parames C. Sil, PhD, Professor, Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VIIM, Calcutta-700054, West Bengal, India. +91 33 2569 3243. +91 33 2350 6790. parames@bosemain.boseinst.ac.in
中文摘要	The present study investigated the oxidative stress responsive cell signaling in nano-copper-induced hepatic dysfunction and cell death. Exposure to nano-copper (18 nm) dose-dependently (200–600 mg/kg bw) reduced the hepatic index, caused oxidative stress and led to hepatic dysfunction. Nano-copper burden also increased the transcriptional activity of NF-κB, up-regulated the expression of phosphorylated p38, ERK1/2 and caused the reciprocal regulation of Bcl-2 family proteins, disruption of mitochondrial membrane potential, release of cytochrome C, formation of apoptosome and activation of caspase 3. DAPI staining, immunofluorescence study, FACS analysis and histological findings also support this observation. Soluble copper (Cu⁺², 110 mg/kg bw)-exposed animals were used as a positive control. Different doses of particulate and soluble forms were used in the study because of different LD₅₀ values. The results suggest that nano-copper induces hepatic dysfunction and cell death via the oxidative stress-dependent signaling cascades and mitochondrial event. Read More: http://informahealthcare.com/doi/abs/10.3109/17435390.2011.552124?journalCode=nan
公开日期	2012-09-05
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/5671]
专题	烟台海岸带研究所_科研共享资源
推荐引用方式 GB/T 7714	Prasenjit Manna,Manoranjan Ghosh,Jyotirmoy Ghosh,et al. Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal[J]. Nanotoxicology,2011,6(1):1-21.
APA	Prasenjit Manna,Manoranjan Ghosh,Jyotirmoy Ghosh,Joydeep Das,&Parames C.Sil.(2011).Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal.Nanotoxicology,6(1),1-21.
MLA	Prasenjit Manna,et al."Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal".Nanotoxicology 6.1(2011):1-21.