The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

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	The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats
	Sun, Yingxin 1,2; Zhang, Juan 3; Yan, Yongjian 3; Chi, Mingfeng 4; Chen, Wenwen 3; Sun, Peng 5; Qin, Song 1,6
刊名	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
	2011-09-01
卷号	32 期号:2 页码:168-174
关键词	C-phycocyanin Paraquat Acute lung injury Lipid peroxidation Inflammation
ISSN号	1382-6689
中文摘要	To investigate the potential protective effect of C-phycocyanin (PC) on paraquat (PQ)-induced acute lung injury, rats were divided into control, PQ-treated and PQ + PC-treated groups. Rats in PQ-treated group were orally administered with 50 mg/kg PQ and rats in PQ + PC-treated group were intraperitoneally injected with 50 mg/kg PC after administration of PQ. At 8, 24, 48 and 72 h after treatments, GSH-Px and SOD activities, MDA levels in plasma and BALF, HYP, NF-kappa B, I kappa B-alpha and TNF-alpha contents in lung tissues were measured. The pathological changes in lung were observed. After treatment with PC, the levels of MDA and the relative contents of NF-kappa B and TNF-alpha were significantly decreased, the activities of GSH-Px and SOD and the relative contents of I kappa B-alpha were significantly increased. The degree of rat lung damage was obviously reduced in PQ + PC-treated group. The results suggested that PC treatment significantly attenuated PQ-induced acute lung injury. (C) 2011 Elsevier B.V. All rights reserved.
英文摘要	To investigate the potential protective effect of C-phycocyanin (PC) on paraquat (PQ)-induced acute lung injury, rats were divided into control, PQ-treated and PQ + PC-treated groups. Rats in PQ-treated group were orally administered with 50 mg/kg PQ and rats in PQ + PC-treated group were intraperitoneally injected with 50 mg/kg PC after administration of PQ. At 8, 24, 48 and 72 h after treatments, GSH-Px and SOD activities, MDA levels in plasma and BALF, HYP, NF-kappa B, I kappa B-alpha and TNF-alpha contents in lung tissues were measured. The pathological changes in lung were observed. After treatment with PC, the levels of MDA and the relative contents of NF-kappa B and TNF-alpha were significantly decreased, the activities of GSH-Px and SOD and the relative contents of I kappa B-alpha were significantly increased. The degree of rat lung damage was obviously reduced in PQ + PC-treated group. The results suggested that PC treatment significantly attenuated PQ-induced acute lung injury. (C) 2011 Elsevier B.V. All rights reserved.
学科主题	Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
收录类别	SCI
原文出处	10.1016/j.etap.2011.04.008
语种	英语
WOS记录号	WOS:000294936700008
公开日期	2012-07-03
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/11972]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Shandong Univ Tradit Chinese Med, Dept Postgrad, Jinan 250014, Peoples R China 3.Shandong Acad Occupat Hlth & Occupat Dis, Jinan 250062, Peoples R China 4.Athletes Rehabil Ctr ShanDong Prov, Jinan 250014, Peoples R China 5.Luye Pharmaceut Ltd Co, Dept Pharmaceut Anal, Yantai 264003, Peoples R China 6.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Lab Biol Resources, Yantai 264003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Sun, Yingxin,Zhang, Juan,Yan, Yongjian,et al. The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2011,32(2):168-174.
APA	Sun, Yingxin.,Zhang, Juan.,Yan, Yongjian.,Chi, Mingfeng.,Chen, Wenwen.,...&Qin, Song.(2011).The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,32(2),168-174.
MLA	Sun, Yingxin,et al."The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 32.2(2011):168-174.