Michael Addition between Isatin and Acrylate Derivatives

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Michael Addition between Isatin and Acrylate Derivatives
	Chen, Gang 1; Tang, Ying 1; Zhang, Jie 1; Wu, Ya 1; Hao, Xiao-Jiang2 ; Mu, Shu-Zhen 3,4
刊名	LETTERS IN ORGANIC CHEMISTRY
	2011-11-01
卷号	8 期号:9 页码:614-617
关键词	Acrylate beta-(2 isatin Michael addition 3-dioxoindolin-1-yl) propanoate
ISSN号	1570-1786
通讯作者	Chen, G (reprint author), Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Peoples R China
英文摘要	A simple and efficient Michael addition of isatin to acrylate in the presence of KOH was described. Methyl beta-(2,3-dioxoindolin-1-yl) propanoate was synthesized firstly by the addition of isatin to methyl acrylate in a feasible approach using 10% KOH as catalyst in DMF with the highest yield of 72.5% under the optimized conditions. A series of beta-(2,3-dioxoindolin-1-yl) propanoate derivatives was synthesized according to this approach and gave moderate to relative high yields. The directive distinct color changes in this reaction were illuminated by the reaction mechanism analysis.
学科主题	Chemistry
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	ANALOGS ; CHEMISTRY ; AMIDES
收录类别	SCI
资助信息	National Science Foundation of China[50874092]; Shaanxi Provincial Education Department[11JK0560, 11JK0591]
语种	英语
WOS记录号	WOS:000299570700002
公开日期	2012-07-25
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/14485]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China 4.Chinese Acad Sci, Guiyang 550002, Peoples R China
推荐引用方式 GB/T 7714	Chen, Gang,Tang, Ying,Zhang, Jie,et al. Michael Addition between Isatin and Acrylate Derivatives[J]. LETTERS IN ORGANIC CHEMISTRY,2011,8(9):614-617.
APA	Chen, Gang,Tang, Ying,Zhang, Jie,Wu, Ya,Hao, Xiao-Jiang,&Mu, Shu-Zhen.(2011).Michael Addition between Isatin and Acrylate Derivatives.LETTERS IN ORGANIC CHEMISTRY,8(9),614-617.
MLA	Chen, Gang,et al."Michael Addition between Isatin and Acrylate Derivatives".LETTERS IN ORGANIC CHEMISTRY 8.9(2011):614-617.