Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme

	Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme
	Hou, Shuhua 1,2; Liu, Wujun 1; Ji, Debin 1,2; Zhao, Zongbao (Kent)1,3
刊名	bioorganic & medicinal chemistry letters
	2011-03-15
卷号	21 期号:6 页码:1667-1669
关键词	Nucleotide analog Enzyme inhibitor Click chemistry Synthesis Malic enzyme
ISSN号	待补充
通讯作者	赵宗保
产权排序	1,1
中文摘要	efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme
英文摘要	eleven triazole moiety-containing nucleotide analogs were synthesized starting form tetra-o-acetylribose in 55-63% total yields. the synthesis involved two key steps, the lipase-mediated selective deacylation of 1-azido-2,3,5-tri-o-acetyl-beta-d-ribofuranoside and the huisgen 1,3-dipolar cycloaddition between terminal alkynes and the 1-azido ribofuranoside derivative. these analogs showed inhibitory effects against a recombinant escherichia coli nad-dependent malic enzyme. (c) 2011 elsevier ltd. all rights reserved.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	chemistry, medicinal ; chemistry, organic
研究领域[WOS]	pharmacology & pharmacy ; chemistry
关键词[WOS]	alkyne 1,3-dipolar cycloaddition ; click-chemistry ; reverse-transcriptase ; in-vitro ; nucleoside ; azide ; ribavirin ; mimics ; agents ; chain
收录类别	SCI
语种	英语
WOS记录号	WOS:000288012800020
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115620]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.CAS, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Hou, Shuhua,Liu, Wujun,Ji, Debin,et al. Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme[J]. bioorganic & medicinal chemistry letters,2011,21(6):1667-1669.
APA	Hou, Shuhua,Liu, Wujun,Ji, Debin,&Zhao, Zongbao .(2011).Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme.bioorganic & medicinal chemistry letters,21(6),1667-1669.
MLA	Hou, Shuhua,et al."Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme".bioorganic & medicinal chemistry letters 21.6(2011):1667-1669.