Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example

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	Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example
	Jiang, Huifeng 1,2; Guo, Xiaoxian 1,3; Xu, Lin 1,4; Gu, Zhenglong 1
刊名	MOLECULAR BIOLOGY AND EVOLUTION
	2012-09-01
卷号	29 期号:9 页码:2169-2176
关键词	posttranscriptional regulon evolution of gene regulation yeast
英文摘要	It has been increasingly clear that changes in gene regulation play important roles in physiological and phenotypic evolution. Rewiring gene-regulatory networks, i.e., alteration of the gene-regulation system for different biological functions, has been demonstrated in various species. Posttranscriptional regulons have prominent roles in coordinating gene expression in a variety of eukaryotes. In this study, using Puf4p in fungi as an example, we demonstrate that posttranscriptional regulatory networks can also be rewired during evolution. Although Puf4p is highly conserved in fungi, targets of the posttranscriptional regulon are functionally diverse among known fungal species. In the Saccharomycotina subdivision, target genes of Puf4p mostly conduct function in the nucleolus; however, in the Pezizomycotina subdivision, they are enriched in the mitochondria. Furthermore, we demonstrate different regulation efficiencies of mitochondrial function by PUF proteins in different fungal clades. Our results indicate that rewiring of posttranscription regulatory networks may be an important way of generating genetic novelties in gene regulation during evolution.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
研究领域[WOS]	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
关键词[WOS]	MULTIPLE SEQUENCE ALIGNMENT ; GERMLINE STEM-CELLS ; MESSENGER-RNA ; BINDING PROTEINS ; GIARDIA-LAMBLIA ; GENE-EXPRESSION ; EVOLUTION ; YEAST ; DROSOPHILA ; GENOME
收录类别	SCI
语种	英语
WOS记录号	WOS:000308851600010
公开日期	2012-05-31
内容类型	期刊论文
源URL	[http://localhost/handle/0/240]
专题	天津工业生物技术研究所_酵母基因组工程课题组江会锋_期刊论文
作者单位	1.Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA 2.Chinese Acad Sci, Inst Tianjin Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin, Peoples R China 3.Zhejiang Univ, Coll Life Sci, Hangzhou 310003, Zhejiang, Peoples R China 4.Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA
推荐引用方式 GB/T 7714	Jiang, Huifeng,Guo, Xiaoxian,Xu, Lin,et al. Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example[J]. MOLECULAR BIOLOGY AND EVOLUTION,2012,29(9):2169-2176.
APA	Jiang, Huifeng,Guo, Xiaoxian,Xu, Lin,&Gu, Zhenglong.(2012).Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example.MOLECULAR BIOLOGY AND EVOLUTION,29(9),2169-2176.
MLA	Jiang, Huifeng,et al."Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example".MOLECULAR BIOLOGY AND EVOLUTION 29.9(2012):2169-2176.