Blood lead: Its effect on trace element levels and iron structure in hemoglobin

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2004-2010年

	Blood lead: Its effect on trace element levels and iron structure in hemoglobin
	Jin, C ; Li, Y ; Li, YL ; Zou, Y ; Zhang, GL ; Normura, M ; Zhu, GY
刊名	NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
	2008
卷号	266 期号:16 页码:3607
ISSN号	0168-583X
通讯作者	Li, Y (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
英文摘要	Lead is a ubiquitous environmental pollutant that induce a broad range of physiological and biochemical dysfunctions. The purpose of this study was to investigate its effects on trace elements and the iron structure in hemoglobin. Blood samples were collected from rats that had been exposed to lead. The concentration of trace elements in whole blood and blood plasma was determined by ICP-MS and the results indicate that lead exists mainly in the red blood cells and only about 1-3% in the blood plasma. Following lead exposure, the concentrations of zinc and iron in blood decrease, as does the hemoglobin level. This indicates that the heme biosynthetic pathway is inhibited by lead toxicity and that lead poisoning-associated anemia occurs. The selenium concentration also decreases after lead exposure, which may lead to an increased rate of free radical production. The effect of lead in the blood on iron structure in hemoglobin was determined by EXAFS. After lead exposure, the Fe-O bond length increases by about 0.07 angstrom and the Fe-Np bond length slightly increases, but the Fe-N-epsilon bond length remains unchanged. This indicates that the blood content of Hb increases, but that the content of HbO(2) decreases. (C) 2008 Elsevier B.V. All rights reserved.
学科主题	Chemistry
收录类别	SCI
语种	英语
WOS记录号	WOS:000259429100015
公开日期	2012-04-18
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/7665]
专题	上海应用物理研究所_中科院上海应用物理研究所2004-2010年
推荐引用方式 GB/T 7714	Jin, C,Li, Y,Li, YL,et al. Blood lead: Its effect on trace element levels and iron structure in hemoglobin[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2008,266(16):3607.
APA	Jin, C.,Li, Y.,Li, YL.,Zou, Y.,Zhang, GL.,...&Zhu, GY.(2008).Blood lead: Its effect on trace element levels and iron structure in hemoglobin.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,266(16),3607.
MLA	Jin, C,et al."Blood lead: Its effect on trace element levels and iron structure in hemoglobin".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 266.16(2008):3607.