Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium-99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)-Folic Acid Conjugates

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2004-2010年

	Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium-99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)-Folic Acid Conjugates
	Zhang, YQ ; Sun, YH ; Xu, XP ; Zhang, XZ ; Zhu, H ; Huang, LL ; Qi, YJ ; Shen, YM
刊名	JOURNAL OF MEDICINAL CHEMISTRY
	2010
卷号	53 期号:8 页码:11
ISSN号	0022-2623
通讯作者	Shen, YM (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Baojia Rd, Shanghai 201800, Peoples R China
英文摘要	Three conjugates based on dendrimer PAMAM generation five were synthesized and radiolabeled successfully. To investigate their tumor targeting, the in vitro and in vivo stability, cell uptake, in vivo biodistribution, and micro-SPECT imaging were evaluated, respectively. The conjugate of (99m)Tc labeled PEGylated dendrimer PAMAM folic acid conjugate ((99m)Tc-G5-Ac-pegFA-DTPA) shows much higher uptake in KB cancer cells and accumulated more in the tumor area than that of the other two conjugates. The uptake in KB cells depends on the incubation time. The results of in vivo biodistribution agree with the data obtained from micro-SPECT imaging. These studies show that PEGylation of PAMAM dendrimer folic acid conjugate improves the tumor targeting. Folate-conjugated dendrimer maybe developed to be potential radiopharmaceuticals and targeted drug delivery systems.
学科主题	Pharmacology & Pharmacy
收录类别	SCI
语种	英语
WOS记录号	WOS:000276562400022
公开日期	2012-04-11
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/7077]
专题	上海应用物理研究所_中科院上海应用物理研究所2004-2010年
推荐引用方式 GB/T 7714	Zhang, YQ,Sun, YH,Xu, XP,et al. Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium-99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)-Folic Acid Conjugates[J]. JOURNAL OF MEDICINAL CHEMISTRY,2010,53(8):11.
APA	Zhang, YQ.,Sun, YH.,Xu, XP.,Zhang, XZ.,Zhu, H.,...&Shen, YM.(2010).Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium-99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)-Folic Acid Conjugates.JOURNAL OF MEDICINAL CHEMISTRY,53(8),11.
MLA	Zhang, YQ,et al."Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium-99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)-Folic Acid Conjugates".JOURNAL OF MEDICINAL CHEMISTRY 53.8(2010):11.