Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 资源植物与生物技术所级重点实验室

	Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata
	Xiao, Xiao 1,2; Liu, Xi-Kui 2; Fu, Shao-Bin 1; Sun, Di-An 1
刊名	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
	2011
卷号	13 期号:3 页码:270-275
关键词	microbial transformation biotransformation hydroxylation diosgenin Cunninghamella echinulata CGMCC 3 2000
ISSN号	1028-6020
通讯作者	Sun, DA (reprint author), Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China
英文摘要	Microbial transformation of diosgenin (1) by suspended-cell cultures of the filamentous fungus Cunninghamella echinulata CGMCC 3.2000 was investigated. Incubation of the substrate diosgenin (1) with this fungus led to the isolation of three products: two known compounds, (25R)-spirost-5-en-3,7,12-triol (2) and (25R)-spirost-5-en-3,7,11-triol (3), and a new compound (25R)-spirost-5-en-3,7,11-triol (4). The structural elucidations of the three compounds were achieved mainly by the MS, 1D and 2D NMR spectroscopic methods and comparison with known compounds. C. echinulata CGMCC 3.2000 has not been used before in the biotransformation of diosgenin (1).
学科主题	Plant Sciences; Chemistry; Pharmacology & Pharmacy
类目[WOS]	Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]	CELL-CYCLE ARREST ; STEROID BIOTRANSFORMATION ; OSTEOSARCOMA CELLS ; CONSTITUENTS ; APOPTOSIS ; DIOSCOREA ; SAPOGENINS ; GLYCOSIDES ; EXPRESSION
收录类别	SCI ; IC
资助信息	New Drug Development Project of China[2009ZX09301-003]
语种	英语
WOS记录号	WOS:000288674400013
公开日期	2012-04-10
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/5233]
专题	昆明植物研究所_资源植物与生物技术所级重点实验室
作者单位	1.Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Xiao, Xiao,Liu, Xi-Kui,Fu, Shao-Bin,et al. Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2011,13(3):270-275.
APA	Xiao, Xiao,Liu, Xi-Kui,Fu, Shao-Bin,&Sun, Di-An.(2011).Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,13(3),270-275.
MLA	Xiao, Xiao,et al."Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 13.3(2011):270-275.