INVESTIGATION OF YUNNAN BAIYAO RELEASE BEHAVIOR FROM PVA/WATER-SOLUBLE CHITOSAN/GLYCEROL HYDROGELS PREPARED BY IRRADIATION FOLLOWED BY FREEZE-THAWING

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	INVESTIGATION OF YUNNAN BAIYAO RELEASE BEHAVIOR FROM PVA/WATER-SOLUBLE CHITOSAN/GLYCEROL HYDROGELS PREPARED BY IRRADIATION FOLLOWED BY FREEZE-THAWING
	Yang, XM（杨小敏） ; Chen, XL（陈西良） ; Ma, MW（马明旺） ; Yang, K（杨康） ; Liu, D（刘丹） ; Zhu, ZY(朱智勇）
刊名	ACTA POLYMERICA SINICA
	2009
期号	12 页码:7
关键词	Irradiation followed by freeze-thawing Water soluble chitosan Yunnan Baiyao Drug release
ISSN号	1000-3304
通讯作者	Yang, XM (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
英文摘要	A series of poly(vinyl alcohol)/water-soluble chitosan/glycerol hydrogels were prepared by irradiation followed by freeze-thawing. Yunnan Baiyao was loaded into the hydrogels by solvent sorption technique. The influences of pH,ionic strength, freeze-thawing cycles and PVA concentration on the swelling capacity and Yunnan Baiyao release behavior were investigated. The swelling capacity decreased with increasing ionic strength,and it was larger in acidic media than in neutral media. Much more amount of Yunnan Baiyao could be loaded into PVA/ws-chitosan/glycerol hydrogels than into PVA hydrogels. Yunnan Baiyao release behavior of the former hydrogel showed pH and ionic strength sensitivity due to the existence of ws-chitosan. Larger amount of Yunnan Baiyao was released in pseudo-extracellular fluid solution than in neutral media and only small amount of the drug was released in acidic media and in distilled water, which was opposite to the swelling behavior. However, it was found that the swelling capacity and Yunnan Baiyao release amount both decreased with increasing freeze-thawing cycles and PVA concentration. These results indicated that Yunnan Baiyao release amount in various release media was mainly determined by the ionic exchange capacity between the drug and the ions in the solution. However, the release amount was mainly determined by swelling capacity when the hydrogels were in the same release media for different hydrogels. The swelling rate was much larger than the drug release rate indicating that the drug release rate was mainly diffusion-controlled. The pH sensitive drug release behavior indicated that the hydrogel had potential to be used for the oral delivery of Yunnan Baiyao.
学科主题	Polymer Science
收录类别	SCI
语种	英语
WOS记录号	WOS:000273214300004
公开日期	2012-04-11
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/6949]
专题	上海应用物理研究所_中科院上海应用物理研究所2004-2010年
推荐引用方式 GB/T 7714	Yang, XM,Chen, XL,Ma, MW,et al. INVESTIGATION OF YUNNAN BAIYAO RELEASE BEHAVIOR FROM PVA/WATER-SOLUBLE CHITOSAN/GLYCEROL HYDROGELS PREPARED BY IRRADIATION FOLLOWED BY FREEZE-THAWING[J]. ACTA POLYMERICA SINICA,2009(12):7.
APA	Yang, XM,Chen, XL,Ma, MW,Yang, K,Liu, D,&Zhu, ZY.(2009).INVESTIGATION OF YUNNAN BAIYAO RELEASE BEHAVIOR FROM PVA/WATER-SOLUBLE CHITOSAN/GLYCEROL HYDROGELS PREPARED BY IRRADIATION FOLLOWED BY FREEZE-THAWING.ACTA POLYMERICA SINICA(12),7.
MLA	Yang, XM,et al."INVESTIGATION OF YUNNAN BAIYAO RELEASE BEHAVIOR FROM PVA/WATER-SOLUBLE CHITOSAN/GLYCEROL HYDROGELS PREPARED BY IRRADIATION FOLLOWED BY FREEZE-THAWING".ACTA POLYMERICA SINICA .12(2009):7.