Application of Terahertz Technology in Pharmaceutical Setting

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	Application of Terahertz Technology in Pharmaceutical Setting
	Liu, XH ; Zhao, HW ; Liu, GF ; Zhang, ZY ; Ji, T ; Wu, SW
刊名	PROGRESS IN CHEMISTRY
	2010
卷号	22 期号:11 页码:8
关键词	terahertz (THz) terahertz spectroscopy terahertz imaging active pharmaceutical ingredients (APIs) process analytical technology (PAT)
ISSN号	1005-281X
通讯作者	Zhao, HW (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
英文摘要	Terahertz (THz) technology and its applications are now advancing rapidly This has resulted in a number of promising applications in the fields of homeland security, information and communications, condensed mater physics, global environmental monitoring, nondestructive evaluation, physical and analytical chemistry, biology and medical sciences and many others THz technology including terahertz time-domain spectroscopy (THz-TDS) and terahertz imaging has great potential in pharmaceutical Industry, because It can provide rich and useful information that helps us to understand the structure and property of molecules from a new electromagnetic wave window The innovative progresses in the application of THz technology in the pharmaceutical setting in recent years are reviewed with illustrative examples in this paper THz-TDS has the capability to characterize and quantify the active pharmaceutical ingredients (APIs) in drug materials and final solid dosage forms and to investigate crystallinity, polymorphism, and pseudo-polymorphism THz functional imaging can be used to nondestructively analyze the tablet matrix physicochemical composition, coating thickness, density and internal structure, and the uniformity and integrity of the coat in solid dosage forms due to the pulsed, coherent and frequency-dependent penetration nature of the radiation The applications of THz technology in reaction dynamics and as an on-line process analytical technology (PAT) are also discussed in this review
学科主题	Chemistry
收录类别	SCI
语种	英语
WOS记录号	WOS:000284860900013
公开日期	2012-04-11
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/6841]
专题	上海应用物理研究所_中科院上海应用物理研究所2004-2010年
推荐引用方式 GB/T 7714	Liu, XH,Zhao, HW,Liu, GF,et al. Application of Terahertz Technology in Pharmaceutical Setting[J]. PROGRESS IN CHEMISTRY,2010,22(11):8.
APA	Liu, XH,Zhao, HW,Liu, GF,Zhang, ZY,Ji, T,&Wu, SW.(2010).Application of Terahertz Technology in Pharmaceutical Setting.PROGRESS IN CHEMISTRY,22(11),8.
MLA	Liu, XH,et al."Application of Terahertz Technology in Pharmaceutical Setting".PROGRESS IN CHEMISTRY 22.11(2010):8.