Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production
	Zhang, Wenpeng 1; Xia, Chengfeng 1,2,3; Nadas, Janos 2; Chen, Wenlan 2; Gu, Li 1,4; Wang, Peng George 1,2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2011-04-15
卷号	19 期号:8 页码:2767-2776
关键词	alpha-GalCer NKT cell ligand Computer modeling CD1d NKT TCR
ISSN号	0968-0896
通讯作者	Xia, CF (reprint author), Ohio State Univ, Dept Biochem, 484 W 12th Ave, Columbus, OH 43210 USA
英文摘要	The glycosphingolipid alpha-GalCer has been found to influence mammalian immune system significantly through the natural killer T cells. Unfortunately, the pre-clinical and clinical studies revealed several critical disadvantages that prevented the therapeutic application of alpha-GalCer in treating cancer and other diseases. Recently, the detailed illustration of the CD1d/alpha-GalCer/NKT TCR complex crystal structural, together with other latest structural and biological understanding on glycolipid ligands and NKT cells, provided a new platform for developing novel glycolipid ligands with optimized therapeutic effects. Here, we designed a series of novel aromatic group substituted alpha-GalCer analogues. The biological activity of these analogues was characterized and the results showed the unique substitution group manipulated the immune responses of NKT cells. Computer modeling and simulation study indicated the analogues had unique binding mode when forming CD1d/glycolipid/NKT TCR complex, comparing to original alpha-GalCer. (C) 2010 Published by Elsevier Ltd.
学科主题	Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
类目[WOS]	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	KILLER T-CELLS ; SPONGE AGELAS-MAURITIANUS ; DENDRITIC CELLS ; GALACTOSYLCERAMIDE KRN7000 ; PSEUDOMONAS-AERUGINOSA ; CRYSTAL-STRUCTURE ; CD1 GENES ; NOD MICE ; IN-VIVO ; PHASE-I
收录类别	SCI
资助信息	National Institutes of Health[R21AI083513]; State Key Laboratory of Phytochemistry & Plant Resources in West China
语种	英语
WOS记录号	WOS:000289281600030
公开日期	2012-04-10
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/5519]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA 2.Ohio State Univ, Dept Chem, Columbus, OH 43210 USA 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 4.Shandong Univ, SKLMT, Jinan 250100, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wenpeng,Xia, Chengfeng,Nadas, Janos,et al. Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(8):2767-2776.
APA	Zhang, Wenpeng,Xia, Chengfeng,Nadas, Janos,Chen, Wenlan,Gu, Li,&Wang, Peng George.(2011).Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production.BIOORGANIC & MEDICINAL CHEMISTRY,19(8),2767-2776.
MLA	Zhang, Wenpeng,et al."Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production".BIOORGANIC & MEDICINAL CHEMISTRY 19.8(2011):2767-2776.