Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes

	Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes
	Wang XH ; Wang CY ; Qu KG ; Song YJ ; Ren JS ; Miyoshi D ; Sugimoto N ; Qu XG
刊名	advanced functional materials
	2010
卷号	20 期号:22 页码:3967-3971
关键词	CROSS-CORRELATION SPECTROSCOPY HUMAN CYCLIN A(2) CELL-CYCLE PEPTIDE BEACONS EPITAXIAL GRAPHENE MOLECULAR BEACONS PROTEIN-DETECTION DNA-REPLICATION FLUORESCENCE EXPRESSION
ISSN号	1616-301x
通讯作者	wang xh
中文摘要	cyclin a(2) is a prognostic indicator in early-stage cancer. however, since most of peptide-protein bindings do not produce an easily measurable output signal, this severely hinders homogeneous detection of protein using peptide as detection probe: cyclin a(2) can be detected as low as 0.6 mu m using a well-known p21 ((waf-1)) consensus senquence for a specific cyclin a(2) binding motif, which is incorporated into a tb3+ chelating macrocycle by chemical modification at the n-terminus of cm b. herein, a simple, ultra-sensitive, and selective signal-on fluorescence assay is developed for detection of a prognostic indicator in early-stage cancer, cylin a(2.) graphene oxide (go) is even superior to swnts for cyclin a(2) detection. the direct detection limit using graphene oxide is 0.5 nm, 10-fold better than using swnts, and 1200-fold better than the latest reported value of 0.6 mu m using the tb3+ chelating macrocyle modified p21((waf-1)) peptide.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000285222300017
公开日期	2012-04-25
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/43245]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang XH,Wang CY,Qu KG,et al. Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes[J]. advanced functional materials,2010,20(22):3967-3971.
APA	Wang XH.,Wang CY.,Qu KG.,Song YJ.,Ren JS.,...&Qu XG.(2010).Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes.advanced functional materials,20(22),3967-3971.
MLA	Wang XH,et al."Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes".advanced functional materials 20.22(2010):3967-3971.