Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds
	Wang, Jun-Feng 1,3; Dai, Huan-Qin 2; Wei, Yu-Ling 4; Zhu, Hua-Jie 1; Yan, Yong-Ming 1; Wang, Yue-Hu1 ; Long, Chun-Lin 1; Zhong, Hui-Min 3; Zhang, Li-Xin 2; Cheng, Yong-Xian 1
刊名	CHEMISTRY & BIODIVERSITY
	2010
卷号	7 期号:8 页码:2046-2053
关键词	MULTIDRUG-RESISTANT NATURAL-PRODUCTS WIGHTIANA FLAVONOLIGNANS TUBERCULOSIS
ISSN号	1612-1872
英文摘要	Investigation on the extracts of Hydnocarpus anthelminthica seeds led to the isolation of three new compounds, anthelminthieins A C (1-3, resp). and two known ones, namely chaulmoogric acid (4) and ethyl chaulmoograte (5) Their structures were determined mainly by using spectroscopic techniques The absolute configuration at the cyclopentenyl moiety of compound 2 was rationalized by quantum calculations Base hydrolysis, followed by optical-rotation comparison, allowed assignment of the configuration of chaulmoogric-acid moiety of compounds 3 and 5 Biological assays revealed that compounds 1-5 significantly inhibit Mycobacterium tuberculosis(MTB) growth with MIC values of 5 54. 16 70, 4 38, 9 82, and 16 80 mu M, respectively Compound 3 was found to inhibit the pathway between chorismate and para-aminobenzoic acid (pAba) with a MIC value of 11 3 mu m, representing a new example of pAba inhibitor isolated from a natural source All compounds were not toxic to Candida albicans SC5314 at a concentration up to 100 mu m
学科主题	Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
类目[WOS]	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]	MULTIDRUG-RESISTANT ; NATURAL-PRODUCTS ; WIGHTIANA ; FLAVONOLIGNANS ; TUBERCULOSIS
收录类别	SCI
资助信息	Chinese Academy of Sciences ; Talent Scholarship of Yunnan Youth [2007PY01-48]; National Natural Science Foundation of China [30901849]; Ministry of Science and Technology of China [2008ZX09401-004]; MOST [2007DFB31620]; 863 Hi-Tech Research and Development Program of China [2006AA09Z402, 2007AA09Z443]; Hundred Talents Program
语种	英语
WOS记录号	WOS:000281489400016
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/4058]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China 3.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao, Peoples R China 4.Yunnan Acad Tobacco Sci, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jun-Feng,Dai, Huan-Qin,Wei, Yu-Ling,et al. Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds[J]. CHEMISTRY & BIODIVERSITY,2010,7(8):2046-2053.
APA	Wang, Jun-Feng.,Dai, Huan-Qin.,Wei, Yu-Ling.,Zhu, Hua-Jie.,Yan, Yong-Ming.,...&Cheng, Yong-Xian.(2010).Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds.CHEMISTRY & BIODIVERSITY,7(8),2046-2053.
MLA	Wang, Jun-Feng,et al."Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds".CHEMISTRY & BIODIVERSITY 7.8(2010):2046-2053.