Structural basis of molecular logic OR in a dual-sensor histidine kinase | |
Shin, Heewhan1; Ren, Zhong1; Zeng, Xiaoli1,3; Bandara, Sepalika1; Yang, Xiaojing1,2 | |
刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
2019-10-01 | |
卷号 | 116期号:40页码:19973-19982 |
关键词 | photoreceptor signal integration phosphorylation molecular logic dynamic crystallography |
ISSN号 | 0027-8424 |
DOI | 10.1073/pnas.1910855116 |
英文摘要 | Signal detection and integration by sensory proteins constitute the critical molecular events as living organisms respond to changes in a complex environment. Many sensory proteins adopt a modular architecture that integrates the perception of distinct chemical or physical signals and the generation of a biological response in the same protein molecule. Currently, how signal perception and integration are achieved in such a modular, often dimeric, framework remains elusive. Here, we report a dynamic crystallography study on the tandem sensor domains of a dual-sensor histidine kinase PPHK (phosphorylation-responsive photosensitive histidine kinase) that operates a molecular logic OR, by which the output kinase activity is modulated by a phosphorylation signal and a light signal. A joint analysis of similar to 170 crystallographic datasets probing different signaling states shows remarkable dimer asymmetry as PPHK responds to the input signals and transitions from one state to the other. Supported by mutational data and structural analysis, these direct observations reveal the working mechanics of the molecular logic OR in PPHK, where the light-induced bending of a long signaling helix at the dimer interface is counteracted by the ligand-induced structural changes from a different sensor domain. We propose that the logic OR of PPHK, together with an upstream photoreceptor, implements a "long-pass" red light response distinct from those accomplished by classical phytochromes. |
资助项目 | Michigan Economic Development Corporation ; Michigan Technology TriCorridor[085P1000817] ; US Department of Energy, Office of Science, Office of Basic Energy Sciences[DE-AC02-06CH11357] ; NIH[R01EY024363] ; University of Illinois at Chicago ; Chicago Biomedical Consortium[CBC C-086] |
WOS关键词 | PHOTOACTIVE YELLOW PROTEIN ; SIGNAL-TRANSDUCTION ; CRYSTAL-STRUCTURE ; PHYTOCHROME ; RESOLUTION ; TIME ; BACTERIOPHYTOCHROME ; MECHANISM ; REVEALS ; MODULE |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | NATL ACAD SCIENCES |
WOS记录号 | WOS:000488828000038 |
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内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/34451] |
专题 | 水生生物研究所_藻类生物学及应用研究中心_期刊论文 |
通讯作者 | Yang, Xiaojing |
作者单位 | 1.Univ Illinois, Dept Chem, Chicago, IL 60607 USA 2.Univ Illinois, Dept Ophthalmol & Vis Sci, Chicago, IL 60607 USA 3.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Shin, Heewhan,Ren, Zhong,Zeng, Xiaoli,et al. Structural basis of molecular logic OR in a dual-sensor histidine kinase[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(40):19973-19982. |
APA | Shin, Heewhan,Ren, Zhong,Zeng, Xiaoli,Bandara, Sepalika,&Yang, Xiaojing.(2019).Structural basis of molecular logic OR in a dual-sensor histidine kinase.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(40),19973-19982. |
MLA | Shin, Heewhan,et al."Structural basis of molecular logic OR in a dual-sensor histidine kinase".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.40(2019):19973-19982. |
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