Apigenin from daily vegetable celery can accelerate bone defects healing

	Apigenin from daily vegetable celery can accelerate bone defects healing
	Jiang, Lei; Liu, Zenggen; Cui, Yulei; Shao, Yun; Tao, Yanduo; Mei, Lijuan
刊名	JOURNAL OF FUNCTIONAL FOODS
	2019
卷号	54
关键词	Skull defect Celery Apigenin Mesenchymal stem cells Wnt
英文摘要	Apigenin, a natural compound in celery, is found to have pro-osteogenesis capacity by screening in our previous work. This study is focused on its pro-osteogenesis mechanism evaluation. The pro-osteogenesis effect of apigenin (50 mg/kg/day), was evaluated in skull defected (SD) mice by monitoring changes in bone histomor-phometry index, formation of new osteoblasts from MSCs and changes in the synthesis of pro-osteogenic cytokines. Signal pathways were investigated by QPCR, Western blot and immunofluorescence. Apigenin has significant pro-osteogenesis effect in vivo, which can promote osteoblasts formation, the expression of osteoblasts-specific marker genes and osteoblasts marker protein in vitro. From the perspective of molecular biology, apigenin promotes osteoblasts formation and the activation of Wnt pathway as well as the induction and nuclei translocation of beta-catenin. Driven by the results of this study, celery might be a useful alternative functional food in helping bone defects regeneration.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/59841]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Jiang, Lei,Liu, Zenggen,Cui, Yulei,et al. Apigenin from daily vegetable celery can accelerate bone defects healing[J]. JOURNAL OF FUNCTIONAL FOODS,2019,54.
APA	Jiang, Lei,Liu, Zenggen,Cui, Yulei,Shao, Yun,Tao, Yanduo,&Mei, Lijuan.(2019).Apigenin from daily vegetable celery can accelerate bone defects healing.JOURNAL OF FUNCTIONAL FOODS,54.
MLA	Jiang, Lei,et al."Apigenin from daily vegetable celery can accelerate bone defects healing".JOURNAL OF FUNCTIONAL FOODS 54(2019).