Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

	Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau
	Guo, Jiajia; Zhang, Dan; Yu, Chao; Yao, Ling; Chen, Zhuo; Tao, Yanduo; Cao, Weiguo
刊名	MOLECULES
	2019
卷号	24 期号:9
关键词	LC-MS anti-oxidation analgesia formalin test Tibetan plant
英文摘要	Incarvillea compacta Maxim is a traditional Tibetan plant widely used to treat rheumatic pain and bruises. We conducted qualitative analyses by liquid chromatography-mass spectrometry and quantitative analyses of the total phenols, flavonoids, and alkaloids content of different extracts of I. compacta Maxim. Antioxidant and analgesic activity were analyzed. The results showed that the methanol extract had the highest content of the various ingredients. A total of 25 constituents were identified, of which compounds 1-23 were found for the first time in this plant. The water extract had the highest capacity to clear free radicals in the antioxidant test. The water extract had dose-dependent analgesic effects in the first and second phase in a formalin test. The latency of pain from a hot-plate test was augmented by the water extract when the dose was greater than or equal to 30 g/kg. The water extract significantly decreased the amount of writhing in a dose-dependent manner compared with the control group in the acetic acid-induced writhing test. These results showed that I. compacta Maxim is a new antioxidant and analgesic agent, and this study provides information on its ingredients for further study.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/59794]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Guo, Jiajia,Zhang, Dan,Yu, Chao,et al. Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau[J]. MOLECULES,2019,24(9).
APA	Guo, Jiajia.,Zhang, Dan.,Yu, Chao.,Yao, Ling.,Chen, Zhuo.,...&Cao, Weiguo.(2019).Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau.MOLECULES,24(9).
MLA	Guo, Jiajia,et al."Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau".MOLECULES 24.9(2019).