A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain

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	A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain
	Liu, Xiang-Hong 1,2; Tang, Xiao-Zhen 2; Miao, Feng-Ping1 ; Ji, Nai-Yun1
刊名	NATURAL PRODUCT COMMUNICATIONS
	2011-09-01
卷号	6 期号:9 页码:1243-1246
关键词	3-hydroxy-5-(hydroxymethyl)-4-(4 '-hydroxyphenoxy)pyrrolidin-2-one Gibberella zeae Fusarium graminearum Codium fragile
ISSN号	1934-578X
通讯作者	Ji, NY, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. nyji@yic.ac.cn
产权排序	[Liu, XH; Miao, FP; Ji, NY] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Liu, XH; Tang, XZ] Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China
中文摘要	A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines.
英文摘要	A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines.
学科主题	Pharmacology & Pharmacy; Food Science & Technology
研究领域[WOS]	Pharmacology & Pharmacy ; Food Science & Technology
关键词[WOS]	FUSARIUM-ROSEUM ATCC-28114 ; MINOR METABOLITES ; FRUIT BODIES ; CONSTITUENTS ; GRAMINEARUM
收录类别	SCI
资助信息	Chinese Academy of Sciences for Key Topics in Innovation Engineering[KZCX2-YW-QN209, KSCX2-EW-G-12B]; Shandong Province Natural Science Foundation[ZR2009BQ021]; Yantai Municipal Sci-Tech Development Program[2009164]; Foundation of the Chinese Academy of Sciences
语种	英语
WOS记录号	WOS:000294381500008
公开日期	2011-11-11
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/5114]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,et al. A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain[J]. NATURAL PRODUCT COMMUNICATIONS,2011,6(9):1243-1246.
APA	Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,&Ji, Nai-Yun.(2011).A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain.NATURAL PRODUCT COMMUNICATIONS,6(9),1243-1246.
MLA	Liu, Xiang-Hong,et al."A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain".NATURAL PRODUCT COMMUNICATIONS 6.9(2011):1243-1246.