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	Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients
	Xiong, Qian; Ge, Feng
刊名	EXPERT REVIEW OF PROTEOMICS
	2011-08-01
卷号	8期号:4页码:439-442
关键词	2D-DIGE multiple myeloma predictive biomarkers thalidomide
ISSN号	1478-9450
通讯作者	Ge, F (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; gefeng@ihb.ac.cn
中文摘要	Predicting response to thalidomide-based therapy remains a challenging task faced by clinicians in the treatment of multiple myeloma. The pioneering work reported by Rajpal et al. moves one step further towards solving this challenge. They developed a proteomics-based approach that combines immunodepletion, 2D-difference gel electrophoresis analysis and mass spectrometry to search for serum proteins with expressions that show significant correlations to thalidomide treatment. This integrated approach allowed them to identify a panel of protein biomarkers. By using ELISA-based validation and strict statistical analysis, the authors have achieved an overall 84.0% predictive accuracy, with associated sensitivity and specificity values of 81.8 and 86.2%, respectively. Their methods and significant findings are reviewed within this article. This panel of biomarkers may not only guide initial therapy, but can also provide direct implications for personalized medicine in multiple myeloma patients.
英文摘要	Predicting response to thalidomide-based therapy remains a challenging task faced by clinicians in the treatment of multiple myeloma. The pioneering work reported by Rajpal et al. moves one step further towards solving this challenge. They developed a proteomics-based approach that combines immunodepletion, 2D-difference gel electrophoresis analysis and mass spectrometry to search for serum proteins with expressions that show significant correlations to thalidomide treatment. This integrated approach allowed them to identify a panel of protein biomarkers. By using ELISA-based validation and strict statistical analysis, the authors have achieved an overall 84.0% predictive accuracy, with associated sensitivity and specificity values of 81.8 and 86.2%, respectively. Their methods and significant findings are reviewed within this article. This panel of biomarkers may not only guide initial therapy, but can also provide direct implications for personalized medicine in multiple myeloma patients.
学科主题	Biochemistry & Molecular Biology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemical Research Methods
研究领域[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	QUANTITATIVE PROTEOMICS ; SYSTEMS BIOLOGY
收录类别	SCI
语种	英语
WOS记录号	WOS:000294139500008
公开日期	2011-11-09
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/16357]
专题	水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
作者单位	Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Xiong, Qian,Ge, Feng. Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients[J]. EXPERT REVIEW OF PROTEOMICS,2011,8(4):439-442.
APA	Xiong, Qian,&Ge, Feng.(2011).Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients.EXPERT REVIEW OF PROTEOMICS,8(4),439-442.
MLA	Xiong, Qian,et al."Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients".EXPERT REVIEW OF PROTEOMICS 8.4(2011):439-442.

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