Simulated studies on the biological effects of space radiation on quiescent human fibroblasts

doi:10.1016/j.asr.2013.06.030

	Simulated studies on the biological effects of space radiation on quiescent human fibroblasts
	Hu, Wentao 2,4; Zhou, Guangming2 ; Wang, Tieshan 3; Wang, Jufang2 ; Li, Yinghui 1; Li, He2 ; Matsumoto, Yoshitaka 5; Liu, Cuihua 5; Hirayama, Ryoichi 5; Furusawa, Yoshiya 5
刊名	ADVANCES IN SPACE RESEARCH
	2013-10-01
卷号	52 页码:1314-1319
关键词	Quiescent Cells Space Radiation Hze Particles Risk Assessment
ISSN号	0273-1177
DOI	10.1016/j.asr.2013.06.030
文献子类	Article
英文摘要	High charge and energy (HZE) particles are severe risk to manned long-term outer space exploration. Studies on the biological effects of space HZE particles and the underlying mechanisms are essential to the accurate risk assessment and the development of efficient countermeasure. Since majority of the cells in human body stay quiescent (G0 phase), in this study, we established G0 cell and G1 cell models by releasing human normal embryonic lung fibroblast cells from contact inhibition and studied the radiation toxicity of various kinds of HZE particles. Results showed that all of the particles were dose-dependently lethal and G0 cells were more radioresistant than G1 cells. We also found that 53BP1 foci were induced in a LET- and fluence-dependent manner and fewer foci were induced in G0 cells than G1 cells, however, the decrease of foci in 24 h after irradiation was highly relevant to the type of particles. These results imply that even though health risk of space radiation is probably overestimated by the data obtained with exponentially growing cells, whose radiosensitivity is similar to G1 cells, the risk of space HZE particles is un-ignorable and accurate assessment and mechanistic studies should be deepened. The diverse abilities of G0 cells and G1 cells in repairing DNA damages induced by HZE particles emphasize the importance in studying the impact of HZE particles on DNA damage repair pathways. (C) 2013 COSPAR. Published by Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundations of China[10979062] ; National Natural Science Foundations of China[U1232125] ; National Natural Science Foundations of China[31270895]
WOS关键词	CHROMOSOME-ABERRATIONS ; IONIZING-RADIATION ; HUMAN-LYMPHOCYTES ; CELL-CYCLE ; REPAIR ; IONS ; IRRADIATION ; DAMAGE
WOS研究方向	Astronomy & Astrophysics ; Geology ; Meteorology & Atmospheric Sciences
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000325045800012
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/48311]
专题	近代物理研究所_生物物理研究室
通讯作者	Zhou, Guangming
作者单位	1.Astronaut Ctr China, State Key Lab Space Med Fundamentat & Applicat, Beijing 100094, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Space Radiobiol, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Chiba 2638555, Japan
推荐引用方式 GB/T 7714	Hu, Wentao,Zhou, Guangming,Wang, Tieshan,et al. Simulated studies on the biological effects of space radiation on quiescent human fibroblasts[J]. ADVANCES IN SPACE RESEARCH,2013,52:1314-1319.
APA	Hu, Wentao.,Zhou, Guangming.,Wang, Tieshan.,Wang, Jufang.,Li, Yinghui.,...&Ding, Nan.(2013).Simulated studies on the biological effects of space radiation on quiescent human fibroblasts.ADVANCES IN SPACE RESEARCH,52,1314-1319.
MLA	Hu, Wentao,et al."Simulated studies on the biological effects of space radiation on quiescent human fibroblasts".ADVANCES IN SPACE RESEARCH 52(2013):1314-1319.