Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by gamma-ray irradiation in mice

doi:10.18632/oncotarget.18487

CORC > 近代物理研究所 > 中国科学院近代物理研究所 > 空间辐射生物研究室

	Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by gamma-ray irradiation in mice
	Quan, Dongqin 5; Li, Xiaoman 1,2,4,5; Ma, Dehui 3; Zha, Xiaodan 3; Pan, Dong 1,2,4; Sun, Manji 5; Hu, Burong1,4 ; Zhao, Baoquan 5
刊名	ONCOTARGET
	2017-09-05
卷号	8 页码:60789-60808
关键词	ilomastat radiation-induced lung injury pneumonitis lung fibrosis MMPs Pathology Section
ISSN号	1949-2553
DOI	10.18632/oncotarget.18487
英文摘要	Lung injury is one of the pathological features in human or animal after radiation and the main side effect for patient after lung cancer radiotherapy. The efficient protective strategy still needs to exploit and the underlying mechanisms remain to be investigated. We found that the expression and activity of matrix metalloproteinases (MMPs) significantly increased at the early stage of radiation-induced lung injury (RILI). Pretreatment with Ilomastat, a synthetic inhibitor of MMPs, decreased the expression and activity of MMPs and significantly alleviated the lung inflammation and fibrosis in the irradiated mice, as well as enhanced the survival of irradiated mice. In addition, the levels of TGF-beta, IL-6, TNF-alpha and IL-1 beta in the tissues dramatically reduced in the irradiated mice pretreated with Ilomastat. Furthermore, our experiments in vitro also showed that radiation significantly increased the MMPs activity, and Ilomastat pretreatment inhibited the activity of MMPs activated by irradiation and increased the cell survival. It is the first report, to our knowledge, to demonstrate that Ilomastat is a potential effective reliever for RILI and MMPs may play important roles in the process of RILI.
资助项目	National Key Scientific Instrument and Equipment Development Project of China[2012YQ03014210] ; National Key Scientific Instrument and Equipment Development Project of China[2012YQ03014211] ; National Natural Science Foundation of China[U1432121] ; National Natural Science Foundation of China[81173572]
WOS关键词	TUMOR-NECROSIS-FACTOR ; GROWTH-FACTOR-BETA ; IDIOPATHIC PULMONARY-FIBROSIS ; MATRIX METALLOPROTEINASES ; RADIATION PNEUMONITIS ; EXTRACELLULAR-MATRIX ; FACTOR-ALPHA ; MOUSE LUNG ; TGF-BETA ; CELLS
WOS研究方向	Oncology ; Cell Biology
语种	英语
出版者	IMPACT JOURNALS LLC
WOS记录号	WOS:000409254200006
资助机构	National Key Scientific Instrument and Equipment Development Project of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/45569]
专题	近代物理研究所_空间辐射生物研究室
通讯作者	Hu, Burong; Zhao, Baoquan
作者单位	1.Chinese Acad Sci, Inst Modern Phys, CAS Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Inner Mongolia Univ Nationalities, Coll Anim Sci & Technol, Tong Liao, Peoples R China 4.Key Lab Space Radiobiol Gansu Prov, Lanzhou, Gansu, Peoples R China 5.Acad Mil Med Sci, Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Quan, Dongqin,Li, Xiaoman,Ma, Dehui,et al. Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by gamma-ray irradiation in mice[J]. ONCOTARGET,2017,8:60789-60808.
APA	Quan, Dongqin.,Li, Xiaoman.,Ma, Dehui.,Zha, Xiaodan.,Pan, Dong.,...&Zhao, Baoquan.(2017).Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by gamma-ray irradiation in mice.ONCOTARGET,8,60789-60808.
MLA	Quan, Dongqin,et al."Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by gamma-ray irradiation in mice".ONCOTARGET 8(2017):60789-60808.