Adaptive hormetic response of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation

doi:10.1016/j.asr.2006.03.030

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	Adaptive hormetic response of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation
	Zhang, Hong; Xie, Yi; Zhou, Qingming; Liu, Bing; Li, Wenjian; Li, Xiaoda; Duan, Xin; Yuan, Zhigang; Zhou, Guangming; Min, Fengling
刊名	ADVANCES IN SPACE RESEARCH
	2006
卷号	38 期号:6 页码:1148-1151
关键词	C-12(6+) heavy ion Co-60 gamma-ray low-dose pre-exposure mouse pituitary growth hormone (GH) adaptive hormetic response
ISSN号	0273-1177
DOI	10.1016/j.asr.2006.03.030
英文摘要	The brain of the Kun-Ming strain mice were irradiated with 0.05 Gy of C-12(6+) ion or Co-60 gamma-ray as the pre-exposure dose, and were then irradiated with 2 Gy of 12C6+ ion or Co-60 gamma-ray as challenging irradiation dose at 4 h after per-exposure. Body weight and serum growth hormone (GH) concentration were measured at 35th day after irradiation. The results showed that irradiation of mouse brain with 2 Gy of C-12(6+) ion or Co-60 gamma-ray significantly diminished mouse body weight and level of serum GH. The relative biological effectiveness values of a 2 Gy dose of C-12(6+) ion calculated with respect to Co-60 gamma-ray were 1.47 and 1.34 for body weight and serum GH concentration, respectively. Pre-exposure with a low-dose (0.05 Gy) of C-12(6+) ion or Co-60 gamma-ray significantly alleviated reductions of mouse body weight and level of serum GH induced by a subsequent high-dose (2 Gy) irradiation. The data suggested that low-dose ionizing irradiation can induce adaptive hormetic responses to the harmful effects of pituitary by subsequent high-dose exposure. (C) 2006 COSPAR. Published by Elsevier Ltd. All rights reserved.
WOS关键词	IONIZING-RADIATION ; HUMAN-LYMPHOCYTES ; SUPEROXIDE-DISMUTASE ; MAMMALIAN-CELLS ; X-RAYS ; PITUITARY DYSFUNCTION ; DNA-DAMAGE ; HORMESIS ; TUMORS ; DEFICIENCY
WOS研究方向	Astronomy & Astrophysics ; Geology ; Meteorology & Atmospheric Sciences
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000202988300020
公开日期	2010-10-29
内容类型	期刊论文
源URL	[http://ir.imp.cas.cn/handle/113462/6095]
专题	近代物理研究所_近代物理研究所知识存储（2010之前）
通讯作者	Zhang, Hong
作者单位	Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hong,Xie, Yi,Zhou, Qingming,et al. Adaptive hormetic response of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation[J]. ADVANCES IN SPACE RESEARCH,2006,38(6):1148-1151.
APA	Zhang, Hong.,Xie, Yi.,Zhou, Qingming.,Liu, Bing.,Li, Wenjian.,...&Min, Fengling.(2006).Adaptive hormetic response of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation.ADVANCES IN SPACE RESEARCH,38(6),1148-1151.
MLA	Zhang, Hong,et al."Adaptive hormetic response of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation".ADVANCES IN SPACE RESEARCH 38.6(2006):1148-1151.