Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways

doi:10.1016/j.pbb.2014.08.005

	Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways
	Xie, Yi 1,2,3; Zhao, Qiu Yue 1,2,3,4; Li, Hong Yan 1,2,3,4; Zhou, Xin 1,2,3; Liu, Yang 1,2,3; Zhang, Hong1,2,3
刊名	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
	2014-11-01
卷号	126 页码:181-186
关键词	Curcumin C-12(6+) Irradiation Oxidative Stress Cerebral Injuries Nrf2 Pathway Mice
ISSN号	0091-3057
DOI	10.1016/j.pbb.2014.08.005
文献子类	Article
英文摘要	Oxidative stress is one of the major mechanisms implicated in carbon ion irradiation. Curcumin is a natural phenolic compound with impressive antioxidant properties. What's more, curcumin is recently proved to exert its effects partly radioprotection. In vivo, we investigated the protective effects of curcumin against C-12(6+) radiation-induced cerebral injury. Our results showed that 4Gy heavy ion radiation-induced spatial strategy and memory decline and reduction of brain superoxide dismutase (SOD) activity levels were all consistently improved by curcumin, and the augmentation of cerebral malonaldehyde (MDA) was lowered by curcumin. Furthermore, both the cerebral cells nuclear erythroid 2-related factor 2 (Nrf2) protein and three typically recognized Nrf2 downstream genes, NAD(P)H quinine oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and gamma-glutamyl cysteine synthetase (gamma-GCS) were consistently up-regulated in curcumin-pretreated mice. Our study confirmed the antagonistic roles of curcumin to counteract radiation-induced cerebral injury in vivo and suggested that the potent Nrf2 activation capability might be valuable for the protective effects of curcumin against radiation. This provides a potential useful radioprotection dietary component for human populations. (C) 2014 Elsevier Inc. All rights reserved.
WOS关键词	HIPPOCAMPAL DENTATE GYRUS ; NEURODEGENERATIVE DISEASES ; INDUCED INHIBITION ; GAMMA-IRRADIATION ; OXIDATIVE DAMAGE ; RESPONSE ELEMENT ; SPACE RADIATION ; MICE ; NEUROGENESIS ; DYSFUNCTION
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000345471200024
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/49233]
专题	中国科学院近代物理研究所
通讯作者	Zhang, Hong
作者单位	1.Chinese Acad Sci, Inst Modem Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Xie, Yi,Zhao, Qiu Yue,Li, Hong Yan,et al. Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2014,126:181-186.
APA	Xie, Yi,Zhao, Qiu Yue,Li, Hong Yan,Zhou, Xin,Liu, Yang,&Zhang, Hong.(2014).Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,126,181-186.
MLA	Xie, Yi,et al."Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 126(2014):181-186.