Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases

doi:10.16476/j.pibb.2017.0222

	Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases
	Yang Shi-Feng 1,2; Sun Chao 2,3; Wang Yu-Pei 2,3; Chen Yu-Hong 2,3; Zhang Qian-Jing 2,3; Zhang Hong1,2,3
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2018-03-01
卷号	45 页码:297-304
关键词	mitochondrial transplantation mitochondrial dysfunction cerebral ischemia myocardial-ischemia-reperfusion injury tumor
ISSN号	1000-3282
DOI	10.16476/j.pibb.2017.0222
其他题名	线粒体移植在治疗线粒体缺陷疾病中的研究进展
英文摘要	Mitochondrion are one of the most important organelles in eukaryotic cells, the main function of which is to provide energy for the survival of cells. The abnormal mitochondrial can cause lesions in cells and even organs, and a growing number of diseases have been linked to mitochondrial defects. Mitochondrial transplantation, an intrusive therapy, which isolated the mitochondria from the normal parts of the patient and then inject it into the damaged or absent areas, so that the injured cells can be treated and the organ functions return to normal. As a novel therapeutic strategy, the manner has emerged in the basic research of some diseases, especially in the field of acute myocardial ischemia reperfusion injury, which has been developed to the clinical trial stage. Based on the origin of mitochondria, several feasible methods of mitochondrial transplantation in the experimental phase were summarized. In addition, the protection of cerebral ischemia/induced neuronal injury and tumor therapy by mitochondria transplantation were also introduced. Moreover, the molecular mechanisms of mitochondrial damage and mitochondrial transplantation were discussed, and put forward the research ideas for developing targeted therapeutic biological agents for mitochondrial transplantation. The paper aims to provide a new perspective for curing of mitochondrial deficiency diseases.
资助项目	National Natural Science Foundation of the Joint Fund Key Projects[U1432248] ; Ministry of Science and Technology Key National R D Projects[2016YFC0904600] ; National Natural Science Foundation of China Youth Fund Project[11505245]
WOS关键词	ISCHEMIA-REPERFUSION INJURY ; CYCLIC ADP-RIBOSE ; STEM-CELLS ; CANCER-CELLS ; CALCIUM ; HEART ; ATP ; DYSFUNCTION ; PROTECTS ; RESCUE
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS记录号	WOS:000428323500002
资助机构	National Natural Science Foundation of the Joint Fund Key Projects ; Ministry of Science and Technology Key National R D Projects ; National Natural Science Foundation of China Youth Fund Project
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/47557]
专题	中国科学院近代物理研究所
作者单位	1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yang Shi-Feng,Sun Chao,Wang Yu-Pei,et al. Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2018,45:297-304.
APA	Yang Shi-Feng,Sun Chao,Wang Yu-Pei,Chen Yu-Hong,Zhang Qian-Jing,&Zhang Hong.(2018).Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,45,297-304.
MLA	Yang Shi-Feng,et al."Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 45(2018):297-304.