Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats

doi:10.3967/bes2018.015

	Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats
	Zhang Ya Nan 1,2; Shi Wen Gui 1,2,3; Li He1,2,3 ; Hua Jun Rui 1,2; Feng Xiu 1,2; Wei Wen Jun 1,2,3; Wang Ju Fang 1,2; He Jin Peng 1,2; Lei Su Wen 4
刊名	BIOMEDICAL AND ENVIRONMENTAL SCIENCES
	2018-02-01
卷号	31 页码:126-135
关键词	Bone loss Microgravity Radiation Ultradian rhythms
ISSN号	0895-3988
DOI	10.3967/bes2018.015
英文摘要	Objective To better understand the pathological causes of bone loss in a space environment, including microgravity, ionizing radiation, and ultradian rhythms. Methods Sprague Dawley (SD) rats were randomly divided into a baseline group, a control group, a hindlimb suspension group, a radiation group, a ultradian rhythms group and a combined-three-factor group. After four weeks of hindlimb suspension followed by X-ray exposure and/or ultradian rhythms, biomechanical properties, bone mineral density, histological analysis, microstructure parameters, and bone turnover markers were detected to evaluate bone loss in hindlimbs of rats. Results Simulated microgravity or combined-three factors treatment led to a significant decrease in the biomechanical properties of bones, reduction in bone mineral density, and deterioration of trabecular parameters. Ionizing radiation exposure also showed adverse impact while ultradian rhythms had no significant effect on these outcomes. Decrease in the concentration of the turnover markers bone alkaline phosphatase (bALP), osteocalcin (OCN), and tartrate-resistant acid phosphatase-5b (TRAP-5b) in serum was in line with the changes in trabecular parameters. Conclusion Simulated microgravity is the main contributor of bone loss. Radiation also results in deleterious effects but ultradian rhythms has no significant effect. Combined-three factors treatment do not exacerbate bone loss when compared to simulated microgravity treatment alone.
资助项目	International Science & Technology Cooperation Program of China[2015DFR30940] ; Science and Technology Research Project of Gansu Province[145RTSA012] ; Science and Technology Research Project of Gansu Province[17JR5RA307]
WOS关键词	LONG-DURATION SPACEFLIGHT ; CIRCADIAN-RHYTHMS ; TRABECULAR BONE ; MATURE MICE ; SHIFT WORK ; IN-VIVO ; MODEL ; IRRADIATION ; ASTRONAUTS ; METABOLISM
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种	英语
出版者	CHINESE CENTER DISEASE CONTROL & PREVENTION
WOS记录号	WOS:000427925500005
资助机构	International Science & Technology Cooperation Program of China ; Science and Technology Research Project of Gansu Province
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/46352]
专题	中国科学院近代物理研究所
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, CAS Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Ctr Dis Control & Prevent, Off Hlth Stand, Beijing 102206, Peoples R China
推荐引用方式 GB/T 7714	Zhang Ya Nan,Shi Wen Gui,Li He,et al. Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2018,31:126-135.
APA	Zhang Ya Nan.,Shi Wen Gui.,Li He.,Hua Jun Rui.,Feng Xiu.,...&Lei Su Wen.(2018).Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,31,126-135.
MLA	Zhang Ya Nan,et al."Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 31(2018):126-135.