Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma

doi:10.3892/mmr.2017.6490

	Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma
	Dai, Junqiang 1; Li, Qiao 1; Bing, Zhitong2 ; Zhang, Yinian 1; Niu, Liang 1; Yin, Hang 1; Yuan, Guoqiang 3; Pan, Yawen 1,3
刊名	MOLECULAR MEDICINE REPORTS
	2017-06-01
卷号	15 页码:4109-4115
关键词	medulloblastoma microRNA microRNA profile Gene Expression Omnibus database Ingenuity Pathway Analysis
ISSN号	1791-2997
DOI	10.3892/mmr.2017.6490
英文摘要	Medulloblastoma is the most common malignant brain tumor of the central nervous system among children. Medulloblastoma is an embryonal tumor, of which little is known about the pathogenesis. Several efforts have been made to understand the molecular aspects of its tumorigenic pathways; however, these are poorly understood. microRNA (miRNA), a type of non-coding short RNA, has been proven to be associated with a number of physiological processes and pathological processes of serious diseases, including brain tumors. Differentially expressed miRNAs serve an important role in numerous types of malignancy. The present study aims to define a differentially expressed set of miRNAs in medulloblastoma tumor tissue, compared with normal samples, to improve the understanding of the tumorigenesis. It was identified that 22 miRNAs were upregulated and 26 miRNAs were downregulated in the tumor tissue compared with the normal group. However, when the medulloblastoma tissue was compared with normal cerebellum tissue, 9 miRNAs were identified to be up or downregulated in the tumor samples. The differentially expressed miRNAs in the tumor tissue were identified in order to clarify the networks and pathways of tumorigenesis using Ingenuity Pathway Analysis. Subsequently, key regulatory genes associated with the development of medulloblastoma were identified, including tumor protein p53, insulin like growth factor 1 receptor, argonaute 2, mitogen-activated protein kinases 1 and 3, sirtuin 1 and Y box binding protein 1.
资助项目	Lanzhou Science and Technology Bureau Project[2013-3-27] ; Lanzhou Science and Technology Bureau Project[2015-3-86] ; Gansu Province Health Industry Research Project[GSWSKY-2015-58] ; doctoral research fund of Lanzhou University Second Hospital[ynbskyjj2015-1-02]
WOS关键词	C-MET ; PANCREATIC-CANCER ; LUNG-CANCER ; SIRT1 ; CELLS ; GROWTH ; PROLIFERATION ; TUMORIGENESIS ; CARCINOMA ; MIR-206
WOS研究方向	Oncology ; Research & Experimental Medicine
语种	英语
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000401071600091
资助机构	Lanzhou Science and Technology Bureau Project ; Gansu Province Health Industry Research Project ; doctoral research fund of Lanzhou University Second Hospital
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/44807]
专题	中国科学院近代物理研究所
通讯作者	Pan, Yawen
作者单位	1.Lanzhou Univ, Dept Neurosurg, Hosp 2, 82 Cuiyingmen Rd, Lanzhou 730030, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 3.Lanzhou Univ, Inst Neurol, Hosp 2, Lanzhou 730030, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Dai, Junqiang,Li, Qiao,Bing, Zhitong,et al. Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma[J]. MOLECULAR MEDICINE REPORTS,2017,15:4109-4115.
APA	Dai, Junqiang.,Li, Qiao.,Bing, Zhitong.,Zhang, Yinian.,Niu, Liang.,...&Pan, Yawen.(2017).Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma.MOLECULAR MEDICINE REPORTS,15,4109-4115.
MLA	Dai, Junqiang,et al."Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma".MOLECULAR MEDICINE REPORTS 15(2017):4109-4115.