An Integrative Model of miRNA and mRNA Expression Signature for Patients of Breast Invasive Carcinoma with Radiotherapy Prognosis

doi:10.1089/cbr.2016.2059

	An Integrative Model of miRNA and mRNA Expression Signature for Patients of Breast Invasive Carcinoma with Radiotherapy Prognosis
	Bing, Zhitong1,2,3 ; Tian, Jinhui 1,2; Zhang, Jingyun 1,2; Li, Xiuxia 1,2; Wang, Xiaohu 4; Yang, Kehu 1,2
刊名	CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
	2016-09-01
卷号	31 页码:253-260
关键词	breast invasive carcinoma Cox regression gene expression prognostic radiotherapy
ISSN号	1084-9785
DOI	10.1089/cbr.2016.2059
英文摘要	Radiotherapy is widely used in breast cancer treatment. The radiotherapy for breast invasive carcinoma (BRCA) presents challenges with the complex clinical factors, and too many genes have been found to be associated with BRCA radiotherapy prognosis. The aim of this study was to construct an integrative model to combine the clinical data and RNA expression data (including microRNA and mRNA) to predict the survival durations of BRCA patients with radiotherapy. Also, the authors try to find the key regulation pairs between mRNA and miRNA from prediction. They collected mRNA and microRNA expression profiles and gathered the corresponding clinical data of 73 BRCA patients with radiotherapy from The Cancer Genome Atlas (TCGA). According to an integrative model from univariate Cox regression between RNA expression and patient survival, they classified the patients with radiotherapy into low-risk and high-risk groups. The results showed that nine mRNAs were considered as protective genes and five miRNAs and eight mRNAs were considered as high-risk genes. Moreover, the high-risk group has a significantly shorter survival time in comparison with the low-risk group by the log-rank test (p = 0.0039). The reliability of the gene signature was validated by an independent data set from the Gene Expression Omnibus (GEO). Furthermore, three pairs of miRNA-mRNA, closely associated to survival, were identified. These findings and method may prove valuable for improving the clinical management of BRCA patients with radiotherapy.
WOS关键词	LARGE GENE LISTS ; P53-DEPENDENT APOPTOSIS ; FUNCTIONAL-ANALYSIS ; DNA-DAMAGE ; CANCER ; BIOINFORMATICS ; SURVIVAL ; SUPPRESSION ; DISCOVERY ; MIR-125B
WOS研究方向	Oncology ; Research & Experimental Medicine ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	MARY ANN LIEBERT, INC
WOS记录号	WOS:000383587300004
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/43621]
专题	中国科学院近代物理研究所
通讯作者	Yang, Kehu
作者单位	1.Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, 199 West Donggang Rd, Lanzhou 730000, Gansu, Peoples R China 2.Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 4.Gansu Prov Canc Hosp, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Bing, Zhitong,Tian, Jinhui,Zhang, Jingyun,et al. An Integrative Model of miRNA and mRNA Expression Signature for Patients of Breast Invasive Carcinoma with Radiotherapy Prognosis[J]. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,2016,31:253-260.
APA	Bing, Zhitong,Tian, Jinhui,Zhang, Jingyun,Li, Xiuxia,Wang, Xiaohu,&Yang, Kehu.(2016).An Integrative Model of miRNA and mRNA Expression Signature for Patients of Breast Invasive Carcinoma with Radiotherapy Prognosis.CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,31,253-260.
MLA	Bing, Zhitong,et al."An Integrative Model of miRNA and mRNA Expression Signature for Patients of Breast Invasive Carcinoma with Radiotherapy Prognosis".CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 31(2016):253-260.