Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach

doi:10.1118/1.4941310

	Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach
	Tian, Liheng 1,2,3; Li, Qiang1,2 ; Liu, Xinguo1,2 ; Dai, Zhongying1,2 ; Fu, Tingyan 1,2; He, Pengbo 1,2; Yan, Yuanlin 1,2,3; Ma, Yuanyuan1,2,3 ; Huang, Qiyan1,2,3
刊名	MEDICAL PHYSICS
	2016-03-01
卷号	43 页码:1200-1211
关键词	heavy ion cancer therapy radioactive C-9 beam beta-delayed particle decay RBE enhancement clustered damage
ISSN号	0094-2405
DOI	10.1118/1.4941310
英文摘要	Purpose: To improve the efficacy of heavy ion therapy, beta-delayed particle decay C-9 beam as a double irradiation source for cancer therapy has been proposed. The authors' previous experiment showed that relative biological effectiveness (RBE) values at the depths around the Bragg peak of a C-9 beam were enhanced and compared to its stable counterpart C-12 beam. The purpose of this study was to explore the nature of the biological efficacy enhancement theoretically. Methods: A Monte Carlo simulation study was conducted in this study. First a simplified cell model was established so as to form a tumor tissue. Subsequently, the tumor tissue was imported into the Monte Carlo simulation software package GATE and then the tumor cells were virtually irradiated with comparable C-9 and C-12 beams, respectively, in the simulations. The transportation and particle deposition data of the C-9 and C-12 beams, derived from the GATE simulations, were analyzed with the authors' local effect model implementation so as to deduce cell survival fractions. Results: The particles emitted from the decay process of deposited C-9 particles around a cell nucleus increased the dose delivered to the nucleus and elicited clustered damages around the secondary particles' trajectories. Therefore, compared to the C-12 beam, the RBE value of the C-9 beam increased at the depths around their Bragg peaks. Conclusions: Collectively, the increased local doses and clustered damages due to the decayed particles emitted from deposited C-9 particles led to the RBE enhancement in contrast with the C-12 beam. Thus, the enhanced RBE effect of a C-9 beam for a simplified tumor model was shown theoretically in this study. (C) 2016 American Association of Physicists in Medicine.
资助项目	National Natural Science Foundation of China[U1232207] ; National Natural Science Foundation of China[11075191] ; National Natural Science Foundation of China[11205217] ; National Natural Science Foundation of China[11475231] ; Ministry of Science and Technology of China[2015BAI01B11]
WOS关键词	ION TRACK STRUCTURE ; STRAND BREAKS ; C-9-ION BEAM ; BRAGG PEAK ; THERAPY ; RADIOTHERAPY ; IRRADIATION ; CELLS ; DNA
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS
WOS记录号	WOS:000373707100016
资助机构	National Natural Science Foundation of China ; Ministry of Science and Technology of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/42272]
专题	中国科学院近代物理研究所
通讯作者	Li, Qiang
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 73000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Sch Phys, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tian, Liheng,Li, Qiang,Liu, Xinguo,et al. Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach[J]. MEDICAL PHYSICS,2016,43:1200-1211.
APA	Tian, Liheng.,Li, Qiang.,Liu, Xinguo.,Dai, Zhongying.,Fu, Tingyan.,...&Huang, Qiyan.(2016).Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach.MEDICAL PHYSICS,43,1200-1211.
MLA	Tian, Liheng,et al."Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach".MEDICAL PHYSICS 43(2016):1200-1211.