Chromosomal aberrations induced by C-12(6+) heavy ion irradiation in spermatogonia and spermatocytes of mice

	Chromosomal aberrations induced by C-12(6+) heavy ion irradiation in spermatogonia and spermatocytes of mice
	Zhang, H ; Zheng, RL ; Wang, RY ; Wei, ZQ ; Li, WJ ; Gao, QX ; Chen, WQ ; Wang, ZH ; Han, GW ; Liang, JP
刊名	MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
	1998-02-26
卷号	398 页码:27-31
关键词	C-12(6+) heavy ion chromosomal aberration spermatogonium spermatocyte mouse
ISSN号	0027-5107
英文摘要	The testes of Kun-Ming strain mice were radiated with different doses of C-12(6+) ion or Co-60 gamma-ray. Chromosomal aberrations induced in spermatogonia and spermatocytes were analyzed by the air-drying method. The relative biological effectiveness (RBE) of C-12(6+) ion was calculated with respect to Co-60 gamma-ray for the induction of chromosomal aberrations. The C-12(6+) ion and Co-60 gamma-ray dose-response relationships for chromosomal aberrations were plotted by linear quadratic models. The results showed that there was an increase in frequency of chromosomal aberrations in all the treated groups compared to controls. The RBE values were 1.67 for aberrations of spermatogonia and 1.66 for aberrations of spermatocytes for a dose of 2.0 Gy. Moreover, a different distribution of the various types of aberrations has been found for C-12(6+) ion and Co-60 gamma-ray irradiations. The dose-response relationships for C-12(6+) ion and Co-60 gamma-ray exhibited negative curvature in both spermatogonia and spermatocytes groups: the frequencies of aberrations increased sharply at low doses and exhibited less sharp increases for higher doses, which may be related to an interaction between the chromosomal damage and a block in cell cycle. Our results may provide useful information for the assessment of genetic risks of humans exposed to heavy ions. (C) 1998 Elsevier Science B.V.
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000073726200003
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/35417]
专题	中国科学院近代物理研究所
通讯作者	Zheng, RL
作者单位	1.Lanzhou Univ, Dept Biol, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Applicat Heavy Ions, Lanzhou 730000, Peoples R China 3.Lanzhou Med Coll, First Hosp, Dept Gynecol & Obstet, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Zhang, H,Zheng, RL,Wang, RY,et al. Chromosomal aberrations induced by C-12(6+) heavy ion irradiation in spermatogonia and spermatocytes of mice[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,1998,398:27-31.
APA	Zhang, H.,Zheng, RL.,Wang, RY.,Wei, ZQ.,Li, WJ.,...&Liang, JP.(1998).Chromosomal aberrations induced by C-12(6+) heavy ion irradiation in spermatogonia and spermatocytes of mice.MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,398,27-31.
MLA	Zhang, H,et al."Chromosomal aberrations induced by C-12(6+) heavy ion irradiation in spermatogonia and spermatocytes of mice".MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 398(1998):27-31.