Effectiveness of respiratory-gated radiotherapy with audio-visual biofeedback for synchrotron-based scanned heavy-ion beam delivery | |
He, Pengbo1,2,3; Li, Qiang1,2,3; Zhao, Ting1,2,3; Liu, Xinguo1,2,3; Dai, Zhongying1,2,3; Ma, Yuanyuan1,2,3,4 | |
刊名 | PHYSICS IN MEDICINE AND BIOLOGY |
2016-12-21 | |
卷号 | 61页码:8541-8552 |
关键词 | Scanned Heavy-ion Beam Therapy Target Motion Respiratory Gating Respiratory Guidance Personalized Audio-visual Biofeedback |
ISSN号 | 0031-9155 |
DOI | 10.1088/0031-9155/61/24/8541 |
英文摘要 | A synchrotron-based heavy-ion accelerator operates in pulse mode at a low repetition rate that is comparable to a patient's breathing rate. To overcome inefficiencies and interplay effects between the residual motion of the target and the scanned heavy-ion beam delivery process for conventional free breathing (FB)-based gating therapy, a novel respiratory guidance method was developed to help patients synchronize their breathing patterns with the synchrotron excitation patterns by performing short breath holds with the aid of personalized audiovisual biofeedback (BFB) system. The purpose of this study was to evaluate the treatment precision, efficiency and reproducibility of the respiratory guidance method in scanned heavy-ion beam delivery mode. Using 96 breathing traces from eight healthy volunteers who were asked to breathe freely and guided to perform short breath holds with the aid of BFB, a series of dedicated four-dimensional dose calculations (4DDC) were performed on a geometric model which was developed assuming a linear relationship between external surrogate and internal tumor motions. The outcome of the 4DDCs was quantified in terms of the treatment time, dose-volume histograms (DVH) and dose homogeneity index. Our results show that with the respiratory guidance method the treatment efficiency increased by a factor of 2.23-3.94 compared with FB gating, depending on the duty cycle settings. The magnitude of dose inhomogeneity for the respiratory guidance methods was 7.5 times less than that of the non-gated irradiation, and good reproducibility of breathing guidance among different fractions was achieved. Thus, our study indicates that the respiratory guidance method not only improved the overall treatment efficiency of respiratory-gated scanned heavy-ion beam delivery, but also had the advantages of lower dose uncertainty and better reproducibility among fractions. |
资助项目 | Key Project of the National Natural Science Foundation of China[U1232207] ; National Key Technology Support Program of the Ministry of Science and Technology of China[2015BAI01B11] ; CAS 'Light of West China' Program[29Y662020] ; Gansu Natural Science Foundation[1606RJZA056] ; National Natural Science Foundation of China[11205217] ; National Natural Science Foundation of China[11075191] |
WOS关键词 | Moving Target Irradiation ; Radiation-therapy ; Lung-tumors ; Particle Beams ; Motion ; System ; Surrogates ; Position |
WOS研究方向 | Engineering ; Radiology, Nuclear Medicine & Medical Imaging |
语种 | 英语 |
出版者 | IOP PUBLISHING LTD |
WOS记录号 | WOS:000388688800008 |
资助机构 | Key Project of the National Natural Science Foundation of China ; National Key Technology Support Program of the Ministry of Science and Technology of China ; CAS 'Light of West China' Program ; Gansu Natural Science Foundation ; National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.186/handle/113462/24490] |
专题 | 中国科学院近代物理研究所 |
作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | He, Pengbo,Li, Qiang,Zhao, Ting,et al. Effectiveness of respiratory-gated radiotherapy with audio-visual biofeedback for synchrotron-based scanned heavy-ion beam delivery[J]. PHYSICS IN MEDICINE AND BIOLOGY,2016,61:8541-8552. |
APA | He, Pengbo,Li, Qiang,Zhao, Ting,Liu, Xinguo,Dai, Zhongying,&Ma, Yuanyuan.(2016).Effectiveness of respiratory-gated radiotherapy with audio-visual biofeedback for synchrotron-based scanned heavy-ion beam delivery.PHYSICS IN MEDICINE AND BIOLOGY,61,8541-8552. |
MLA | He, Pengbo,et al."Effectiveness of respiratory-gated radiotherapy with audio-visual biofeedback for synchrotron-based scanned heavy-ion beam delivery".PHYSICS IN MEDICINE AND BIOLOGY 61(2016):8541-8552. |
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