Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells

doi:10.3390/molecules22010036

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	Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells
	Liu, Ming 1; Yin, Hua 2; Qian, Xiaokun 3; Dong, Jianjun 2; Qian, Zhonghua 2; Miao, Jinlai 2,4
刊名	MOLECULES
	2017-01
卷号	22 期号:1
关键词	xanthohumol doxorubicin resistance viability stemness
ISSN号	1420-3049
DOI	10.3390/molecules22010036
英文摘要	Xanthohumol is a unique prenylated flavonoid in hops (Humulus lupulus L.) and beer. Xanthohumol has been shown to possess a variety of pharmacological activities. There is little research on its effect on doxorubicin-resistant breast cancer cells (MCF-7/ADR) and the cancer stem-like cells exiting in this cell line. In the present study, we investigate the effect of xanthohumol on the viability and stemness of MCF-7/ADR cells. Xanthohumol inhibits viability, induces apoptosis, and arrests the cell cycle of MCF-7/ADR cells in a dose-dependent manner; in addition, xanthohumol sensitizes the inhibition effect of doxorubicin on MCF-7/ADR cells. Interestingly, we also find that xanthohumol can reduce the stemness of MCF-7/ADR cells evidenced by the xanthohumol-induced decrease in the colony formation, the migration, the percentage of side population cells, the sphere formation, and the down-regulation of stemness-related biomarkers. These results demonstrate that xanthohumol is a promising compound targeting the doxorubicin resistant breast cancer cells and regulating their stemness, which, therefore, will be applied as a potential candidate for the development of a doxorubicin-resistant breast cancer agent and combination therapy of breast cancer.
资助项目	Qingdao Entrepreneurship & Innovation Pioneers Program[15-10-3-15-(44)-zch]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000395473500036
内容类型	期刊论文
源URL	[http://ir.fio.com.cn/handle/2SI8HI0U/3275]
专题	业务部门_海洋生态研究中心
作者单位	1.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China; 2.State Key Lab Biol Fermentat Engn Beer Preparat, Qingdao 266061, Peoples R China; 3.Jiangxi Agr Univ, Coll Food Sci & Engn, Nanchang 330045, Jiangxi, Peoples R China; 4.State Ocean Adm, Inst Oceanog 1, Key Lab Marine Bioact Subst, Qingdao 266061, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ming,Yin, Hua,Qian, Xiaokun,et al. Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells[J]. MOLECULES,2017,22(1).
APA	Liu, Ming,Yin, Hua,Qian, Xiaokun,Dong, Jianjun,Qian, Zhonghua,&Miao, Jinlai.(2017).Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells.MOLECULES,22(1).
MLA	Liu, Ming,et al."Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells".MOLECULES 22.1(2017).