Potent anti-inflammatory activity of polysaccharides extracted from Blidingia minima and their effect in a mouse model of inflammatory bowel disease

doi:10.1016/j.jff.2019.103494

	Potent anti-inflammatory activity of polysaccharides extracted from Blidingia minima and their effect in a mouse model of inflammatory bowel disease
	Song, Wei ; Li, Yan ; Zhang, Xuelei ; Wang, Zongling 1
刊名	JOURNAL OF FUNCTIONAL FOODS
	2019-10
卷号	61
关键词	Blidingia minima Colon Inflammation Polysaccharides
ISSN号	1756-4646
DOI	10.1016/j.jff.2019.103494
英文摘要	Blidingia minima is a green alga that is ubiquitous on many coastlines. To explore the potentially beneficial effects of polysaccharides extracted from Blidingia minima (BMP), in vitro and in vivo studies were performed using dextran sulfate sodium (DSS)-treated intestinal epithelial cells (IPEC-J2 cells) and mice with DSS-induced colitis, respectively. BMP showed an anti-inflammatory effect on DSS-treated cells. Furthermore, BMP alleviated colitis symptoms in DSS-treated mice. BMP repaired colonic dysfunction, and colonic morphology, infiltration, and the expression of tight junction proteins were all improved. Moreover, the mRNA expression and level of pro-inflammatory cytokines, as well as the phosphorylated protein levels of AKT, I kappa B-alpha, and NF-kappa beta in colonic tissue, were all decreased by BMP supplementation. We suggest that the anti-inflammatory effects of BMP may be associated with the modulation of NF-kappa B pathways. These results promote the potential application of BMP as a novel, next-generation therapeutic for treatment of inflammatory bowel disease.
资助项目	Foundation of Key Laboratory of Integrated Monitoring and Applied Technologies for Marine Harmful Algal Blooms[MATHAB201806]
WOS关键词	DEXTRAN SULFATE SODIUM ; INDUCED OXIDATIVE STRESS ; LARGEST GREEN-TIDE ; GLUTATHIONE SYNTHESIS ; ENTEROMORPHA-PROLIFERA ; SUPPLEMENTATION ; ALGA ; AMPK
WOS研究方向	Food Science & Technology ; Nutrition & Dietetics
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000485205700037
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/30226]
专题	自然资源部第一海洋研究所
通讯作者	Wang, Zongling
作者单位	1.Minist Nat Resources Peoples Republ China, Inst Oceanog 1, Key Lab Sci & Engn Marine Ecol & Environm, Qingdao 266061, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266235, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Song, Wei,Li, Yan,Zhang, Xuelei,et al. Potent anti-inflammatory activity of polysaccharides extracted from Blidingia minima and their effect in a mouse model of inflammatory bowel disease[J]. JOURNAL OF FUNCTIONAL FOODS,2019,61.
APA	Song, Wei,Li, Yan,Zhang, Xuelei,&Wang, Zongling.(2019).Potent anti-inflammatory activity of polysaccharides extracted from Blidingia minima and their effect in a mouse model of inflammatory bowel disease.JOURNAL OF FUNCTIONAL FOODS,61.
MLA	Song, Wei,et al."Potent anti-inflammatory activity of polysaccharides extracted from Blidingia minima and their effect in a mouse model of inflammatory bowel disease".JOURNAL OF FUNCTIONAL FOODS 61(2019).