Effects on larval metamorphosis in the mussel Mytilus coruscus of compounds that act on downstream effectors of G-protein-coupled receptors

doi:10.1017/S0025315416001417

	Effects on larval metamorphosis in the mussel Mytilus coruscus of compounds that act on downstream effectors of G-protein-coupled receptors
	Liang, Xiao 1; Chen, Yu-Ru 1; Gao, Wei 1; Guo, Xing-Pan 1; Ding, De-Wen 2; Yoshida, Asami 3; Osatomi, Kiyoshi 3; Yang, Jin-Long 1,2
刊名	JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM
	2018-03
卷号	98 期号:2 页码:333-339
关键词	Mytilus coruscus larval metamorphosis pharmacological compounds G protein-coupled receptor
ISSN号	0025-3154
DOI	10.1017/S0025315416001417
英文摘要	The metamorphic responses of mussel (Mytilus coruscus) larvae to pharmacological agents affecting G proteins and the adenylate cyclase/cyclic AMP (AC/cAMP) pathway were examined in the laboratory. The G protein activators guanosine 5'-[gamma-imido]triphosphate trisodium salt hydrate and guanosine 5'-[beta-thio]triphosphate tetralithium salt only induced larval metamorphosis in continuous exposure assays, and the G protein inhibitor guanosine 5-[-gamma-thio]diphosphate trilithium salt did not exhibit inducing activity. The non-specific phosphodiesterase inhibitor theophylline and the cAMP-specific phosphodiesterase IV inhibitor 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one exhibited inducing activity, while the non-specific phosphodiesterase inhibitor 3-Isobutyl-1-methylxanthine only showed inducing activity at 10(-4) M in continuous exposure assays. The cyclic nucleotide analogue N-6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt did not exhibit significant inducing activity. Both the adenylate cyclase activator forskolin and the adenylate cyclase inhibitor nitroimidazole exhibited inducing activity at 10(-4) to 10(-3) M concentrations in continuous exposure assays. Among these tested agents, the adenylate cyclase inhibitor (+/-)-miconazole nitrate salt showed the most promising inducing effect. The present results indicate that G protein-coupled receptors and signal transduction by AC/cAMP pathway could mediate metamorphosis of larvae in this species.
资助项目	National Natural Science Foundation of China[41606147] ; National Natural Science Foundation of China[31101885]
WOS关键词	MARINE-INVERTEBRATE LARVAE ; PERNA-CANALICULUS LARVAE ; NEUROACTIVE COMPOUNDS ; KINASE-C ; SIGNAL-TRANSDUCTION ; BALANUS-AMPHITRITE ; BACTERIAL BIOFILMS ; GALLOPROVINCIALIS LAMARCK ; HYDROID HYDRACTINIA ; BARNACLE SETTLEMENT
WOS研究方向	Marine & Freshwater Biology
语种	英语
出版者	CAMBRIDGE UNIV PRESS
WOS记录号	WOS:000426876800011
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/26475]
专题	自然资源部第一海洋研究所
通讯作者	Yang, Jin-Long
作者单位	1.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China 2.State Ocean Adm, Inst Oceanog 1, Marine Ecol Res Ctr, Qingdao 266061, Peoples R China 3.Nagasaki Univ, Grad Sch Fisheries & Environm Sci, Nagasaki 8528521, Japan
推荐引用方式 GB/T 7714	Liang, Xiao,Chen, Yu-Ru,Gao, Wei,et al. Effects on larval metamorphosis in the mussel Mytilus coruscus of compounds that act on downstream effectors of G-protein-coupled receptors[J]. JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM,2018,98(2):333-339.
APA	Liang, Xiao.,Chen, Yu-Ru.,Gao, Wei.,Guo, Xing-Pan.,Ding, De-Wen.,...&Yang, Jin-Long.(2018).Effects on larval metamorphosis in the mussel Mytilus coruscus of compounds that act on downstream effectors of G-protein-coupled receptors.JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM,98(2),333-339.
MLA	Liang, Xiao,et al."Effects on larval metamorphosis in the mussel Mytilus coruscus of compounds that act on downstream effectors of G-protein-coupled receptors".JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM 98.2(2018):333-339.