A note on testing families of hypotheses using graphical procedures

doi:10.1002/sim.6267

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	A note on testing families of hypotheses using graphical procedures
	Maurer, Willi 1; Bretz, Frank 1,2
刊名	STATISTICS IN MEDICINE
	2014-12
卷号	33 期号:30 页码:5340-5346
关键词	adjusted p-value graphical approach group sequential design multiple testing
ISSN号	0277-6715
DOI	10.1002/sim.6267
英文摘要	Regulatory guidelines for drug development suggest a strong control of the familywise error rate, when multiple hypotheses are simultaneously tested in confirmatory clinical trials. Accordingly, a variety of multiple test procedures exist for pharmaceutical trial applications, which are typically defined on a single structured family of null hypotheses. For some confirmatory clinical trials with multiple objectives, however, it is advantageous to address the arising multiplicity problems via grouped families of hypotheses. Graphical test procedures have been developed to construct, visualize, and perform multiple test procedures that are tailored to either a single or multiple families of structured hypotheses of interest. This note complements the existing literature by introducing a general algorithm to calculate adjusted p-values for any sequentially rejective graphical test procedure where the test procedures within the individual families of hypotheses are not necessarily graphical. Copyright (c) 2014 John Wiley & Sons, Ltd.
WOS研究方向	Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
语种	英语
出版者	WILEY
WOS记录号	WOS:000346055000010
内容类型	期刊论文
源URL	[http://10.2.47.112/handle/2XS4QKH4/1658]
专题	上海财经大学
通讯作者	Maurer, Willi
作者单位	1.Novartis Pharma AG, CH-4002 Basel, Switzerland; 2.Shanghai Univ Finance & Econ, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Maurer, Willi,Bretz, Frank. A note on testing families of hypotheses using graphical procedures[J]. STATISTICS IN MEDICINE,2014,33(30):5340-5346.
APA	Maurer, Willi,&Bretz, Frank.(2014).A note on testing families of hypotheses using graphical procedures.STATISTICS IN MEDICINE,33(30),5340-5346.
MLA	Maurer, Willi,et al."A note on testing families of hypotheses using graphical procedures".STATISTICS IN MEDICINE 33.30(2014):5340-5346.