Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network

doi:10.4208/cicp.OA-2016-0262

CORC > 上海财经大学 > 上海财经大学

	Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network
	Yao, Wei 1; Huang, Huaxiong 2,3,4; Miura, Robert M.5
刊名	COMMUNICATIONS IN COMPUTATIONAL PHYSICS
	2018-02
卷号	23 期号:2 页码:440-458
关键词	Cortical spreading depression ion transport porous media partial differential equations finite difference solutions
ISSN号	1815-2406
DOI	10.4208/cicp.OA-2016-0262
英文摘要	Cortical spreading depression (CSD) involves depolarization of neurons and astrocytes due principally to a large increase in extracellular potassium. CSD is also accompanied by large increases in extracellular ATP and is blocked by glutamate N-methyl-D-aspartate (NMDA) receptor antagonists. In a previous study, we used a neuronal model to investigate the instigation of CSD and propagation of CSD wave by increasing extracellular potassium. In this paper, we extend that model by constructing a neuron-astrocyte network and incorporating the effects of ATP via the coupled biochemical pathways involving glutamate and NMDA currents. We show that both the electrical current stimuli and the local elevation in the extracellular ATP or glutamate concentration can lead to CSD in the coupled neuron-astrocyte model, while ATP or glutamate increase fails to induce CSD when the glutamate NMDA channels are blocked. These results can explain both the potassium theory postulated by Graf-stein and glutamate theory by Van Harreveld. Our model showed extracellular potassium plays the key role in CSD instigation and propagation, and glutamate is a key compound mediating CSD by activating NMDA channels through neuron-astrocyte interactive.
WOS研究方向	Physics
语种	英语
出版者	GLOBAL SCIENCE PRESS
WOS记录号	WOS:000426270200004
内容类型	期刊论文
源URL	[http://10.2.47.112/handle/2XS4QKH4/707]
专题	上海财经大学
通讯作者	Huang, Huaxiong
作者单位	1.Fudan Univ, Dept Aeronaut & Astronaut, Shanghai Key Lab Acupuncture Mech & Acupoint Func, 220 Handan Rd, Shanghai 200433, Peoples R China; 2.Shanghai Univ Finance & Econ, 777 Guoding Rd, Shanghai 200433, Peoples R China; 3.York Univ, Dept Math & Stat, Toronto, ON M3J 1P3, Canada; 4.Fields Inst, 222 Coll St, Toronto, ON M5T 3J1, Canada; 5.New Jersey Inst Technol, Dept Math Sci, Newark, NJ 07102 USA
推荐引用方式 GB/T 7714	Yao, Wei,Huang, Huaxiong,Miura, Robert M.. Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network[J]. COMMUNICATIONS IN COMPUTATIONAL PHYSICS,2018,23(2):440-458.
APA	Yao, Wei,Huang, Huaxiong,&Miura, Robert M..(2018).Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network.COMMUNICATIONS IN COMPUTATIONAL PHYSICS,23(2),440-458.
MLA	Yao, Wei,et al."Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network".COMMUNICATIONS IN COMPUTATIONAL PHYSICS 23.2(2018):440-458.