Functional connectivity of the human amygdala in health and in depression

doi:10.1093/scan/nsy032

CORC > 上海财经大学 > 上海财经大学

	Functional connectivity of the human amygdala in health and in depression
	Cheng, Wei 1; Rolls, Edmund T.2,3; Qiu, Jiang 4,5; Xie, Xiongfei 6; Lyu, Wujun 7; Li, Yu 5; Huang, Chu-Chung 8; Yang, Albert C.9; Tsai, Shih-Jen 9; Lyu, Fajin 6
刊名	SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
	2018-06
卷号	13 期号:6 页码:557-568
关键词	depression amygdala orbitofrontal cortex functional connectivity emotion
ISSN号	1749-5016
DOI	10.1093/scan/nsy032
英文摘要	To analyse the functioning of the amygdala in depression, we performed the first voxel-level resting state functional-connectivity neuroimaging analysis of depression of voxels in the amygdala with all other voxels in the brain, with 336 patients with major depressive disorder and 350 controls. Amygdala voxels had decreased functional connectivity (FC) with the orbitofrontal cortex, temporal lobe areas, including the temporal pole, inferior temporal gyrus and the parahippocampal gyrus. The reductions in the strengths of the FC of the amygdala voxels with the medial orbitofrontal cortex and temporal lobe voxels were correlated with increases in the Beck Depression Inventory score and in the duration of illness measures of depression. Parcellation analysis in 350 healthy controls based on voxel-level FC showed that the basal division of the amygdala has high FC with medial orbitofrontal cortex areas, and the dorsolateral amygdala has strong FC with the lateral orbitofrontal cortex and related ventral parts of the inferior frontal gyrus. In depression, the basal amygdala division had especially reduced FC with the medial orbitofrontal cortex, which is involved in reward; and the dorsolateral amygdala subdivision had relatively reduced FC with the lateral orbitofrontal cortex, which is involved in non-reward.
WOS研究方向	Neurosciences & Neurology ; Psychology
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000438330000001
内容类型	期刊论文
源URL	[http://10.2.47.112/handle/2XS4QKH4/617]
专题	上海财经大学
作者单位	1.Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai 200433, Peoples R China; 2.Univ Warwick, Dept Comp Sci, Coventry CV4 7AL, W Midlands, England; 3.Oxford Ctr Computat Neurosci, Oxford, England; 4.Minist Educ, Key Lab Cognit & Personal SWU, Chongqing, Peoples R China; 5.Southwest Univ, Dept Psychol, Chongqing, Peoples R China; 6.Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; 7.Shanghai Univ Finance & Econ, Sch Math, Shanghai 200433, Peoples R China; 8.Natl Yang Ming Univ, Inst Neurosci, Taipei, Taiwan; 9.Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan; 10.Natl Yang Ming Univ, Brain Res Ctr, Taipei, Taiwan;
推荐引用方式 GB/T 7714	Cheng, Wei,Rolls, Edmund T.,Qiu, Jiang,et al. Functional connectivity of the human amygdala in health and in depression[J]. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,2018,13(6):557-568.
APA	Cheng, Wei.,Rolls, Edmund T..,Qiu, Jiang.,Xie, Xiongfei.,Lyu, Wujun.,...&Feng, Jianfeng.(2018).Functional connectivity of the human amygdala in health and in depression.SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,13(6),557-568.
MLA	Cheng, Wei,et al."Functional connectivity of the human amygdala in health and in depression".SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 13.6(2018):557-568.