Prognostic value of imbalanced interhemispheric functional coordination   in early therapeutic efficacy in major depressive disorder

doi:10.1016/j.pscychresns.2016.07.011

CORC > 北京大学 > 工学院

	Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder
	Hou, Zhenghua ; Song, Xiaopeng ; Jiang, Wenhao ; Yue, Yingying ; Yin, Yingying ; Zhang, Yuqun ; Liu, Yijun ; Yuan, Yonggui
刊名	PSYCHIATRY RESEARCH-NEUROIMAGING
	2016
关键词	Major depressive disorder Voxel-mirrored homotopic connectivity Functional magnetic resonance imaging Predictive marker Early treatment response DEFAULT-MODE NETWORK PREFRONTAL CORTEX BRAIN NETWORKS DRUG-NAIVE ANTIDEPRESSANT TREATMENT CONNECTIVITY NETWORKS 1ST-EPISODE METAANALYSIS INSULA ARCHITECTURE
DOI	10.1016/j.pscychresns.2016.07.011
英文摘要	This study aims to explore the early response of antidepressant therapy by measuring the voxel-mirrored homotopic connectivity (VMHC) in major depressive disorder (MDD). Eighty-two MDD patients [n=42 treatment-responsive depression (RD) and n=40 non-responding depression (NRD)] and n=50 normal controls (NC) underwent clinical measures and a magnetic resonance imaging scan, and the VMHC values were calculated. Receiver operating characteristic (ROC) curve analysis was applied to determine the capability of altered VMHC to distinguish NRD. The NRD showed significantly decreased VMHC in bilateral precuneus (PCU) and inferior temporal gyrus (ITG), and increased VMHC in middle frontal gyrus (MFG) and caudate nucleus as compared to RD. When compared with NC, the NRD exhibited reduced VMHC in bilateral cerebellum anterior lobe, thalamus and postcentral gyrus. Moreover, VHMC in medial frontal gyrus, postcentral gyrus and precentral gyrus were significantly decreased in RD. Correlation analysis showed that reduced VMHC in PCU was negatively correlated with the baseline HAMD score of the NRD group. The ROC curve indicated that the combined changes of the three regional VMHC (PCU, ITG and MFG) could effectively identify NRD. The current study suggests that interhemispheric asynchrony may represents a novel neural trait underlying the prediction of early therapeutic outcome in MDD. (C) 2016 Elsevier Ireland Ltd. All rights reserved.; SCI(E); PubMed; ARTICLE; yygylh2000@sina.com; 1-8; 255
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/493354]
专题	工学院
推荐引用方式 GB/T 7714	Hou, Zhenghua,Song, Xiaopeng,Jiang, Wenhao,et al. Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2016.
APA	Hou, Zhenghua.,Song, Xiaopeng.,Jiang, Wenhao.,Yue, Yingying.,Yin, Yingying.,...&Yuan, Yonggui.(2016).Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder.PSYCHIATRY RESEARCH-NEUROIMAGING.
MLA	Hou, Zhenghua,et al."Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder".PSYCHIATRY RESEARCH-NEUROIMAGING (2016).