Hemodynamics in Coronary Arterial Tree of Serial Stenoses

doi:10.1371/journal.pone.0163715

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	Hemodynamics in Coronary Arterial Tree of Serial Stenoses
	Chen, Xi ; Gao, Yang ; Lu, Bin ; Jia, Xinwei ; Zhong, Liang ; Kassab, Ghassan S. ; Tan, Wenchang ; Huo, Yunlong
刊名	PLOS ONE
	2016
关键词	FRACTIONAL FLOW RESERVE ENDOTHELIAL SHEAR-STRESS INTRAVASCULAR ULTRASOUND FLUID-DYNAMICS BLOOD-FLOW DISEASE INTERVENTION BIFURCATION PRESSURE LOCALIZATION
DOI	10.1371/journal.pone.0163715
英文摘要	Serial segmental narrowing frequently occurs in humans, which alters coronary hemodynamics and further affects atherosclerotic progression and plaque formation. The objective of this study was to understand the distribution of hemodynamic parameters in the epicardial left main coronary arterial (LMCA) tree with serial stenoses reconstructed from patient computer tomography angiography (CTA) images. A finite volume method was used in conjunction with the inlet pressure wave and outlet flow resistance. The time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) were determined from the flow field. A stenosis at a mother vessel mainly deteriorated the hemodynamics near the bifurcation while a stenosis at a daughter vessel affected the remote downstream bifurcation. In comparison with a single stenosis, serial stenoses increased the peak pressure gradient along the main trunk of the epicardial left anterior descending arterial tree by > 50%. An increased distance between serial stenoses further increased the peak pressure gradient. These findings have important implications on the diagnosis and treatment of serial coronary stenoses.; Natural Science Foundation of China [11372010]; China MOST Grant [2014DFG32740]; Singapore BMRC Grant [1215c013]; Postdoctoral Science Foundation of China [2014M550009]; California Medical Innovations Institute; SCI(E); PubMed; ARTICLE; tanwch@pku.edu.cn; yhuo@pku.edu.cn; 9; e0163715; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/492824]
专题	工学院
推荐引用方式 GB/T 7714	Chen, Xi,Gao, Yang,Lu, Bin,et al. Hemodynamics in Coronary Arterial Tree of Serial Stenoses[J]. PLOS ONE,2016.
APA	Chen, Xi.,Gao, Yang.,Lu, Bin.,Jia, Xinwei.,Zhong, Liang.,...&Huo, Yunlong.(2016).Hemodynamics in Coronary Arterial Tree of Serial Stenoses.PLOS ONE.
MLA	Chen, Xi,et al."Hemodynamics in Coronary Arterial Tree of Serial Stenoses".PLOS ONE (2016).