Mechanical Characterization of Cancer Cells in Epithelial-mesenchymal Transition Using an Electrodeformation-based Microchip

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	Mechanical Characterization of Cancer Cells in Epithelial-mesenchymal Transition Using an Electrodeformation-based Microchip; Mechanical Characterization of Cancer Cells in Epithelial-mesenchymal Transition Using an Electrodeformation-based Microchip
	Yao Teng ; Mingshu Pang ; Jianyong Huang ; Chunyang Xiong
	2016
关键词	viscosity elasticity metastatic distinguish throughput migration captured phenotype malignancy fitted viscosity elasticity metastatic distinguish throughput migration captured phenotype malignancy fitted
英文摘要	Cancer development and progression not only results in biological and functional abnormalities but also leads to changes in the mechanical and structural characteristics of cells.Numerous studies have shown a strong correlation between cell mechanical properties(stiffness or deformability) and cancer progression and malignancy.For example,the stiffness of metastatic cancer cells from body fluids of patients was reported 70%lower than the benign cells lining the body cavity.The mechanical characterization have been shown to be a promising and alternative way to diagnose cancer.Various techniques to measure cell mechanical properties have been utilized including AFM,micropipette aspiration,hydrodynamic stretching,optical tweezer,and electrodeformation.In particular,electrodeformation has advantages over some of these techniques in simple device,easy of use,easy to parallelize and automate.Besides,it is more suitable for whole cell mechanical characterization without destructive manner.Electrodeformation utilize...; Cancer development and progression not only results in biological and functional abnormalities but also leads to changes in the mechanical and structural characteristics of cells.Numerous studies have shown a strong correlation between cell mechanical properties(stiffness or deformability) and cancer progression and malignancy.For example,the stiffness of metastatic cancer cells from body fluids of patients was reported 70%lower than the benign cells lining the body cavity.The mechanical characterization h; Dalian Maritime University (China)、Waterloo Institute for Nanotechnology (Canada)、Beijing International Center for Theoretical a; 1
会议录	2016年大连国际微流控和芯片实验室大会
语种	英语
内容类型	会议论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/479975]
专题	工学院
推荐引用方式 GB/T 7714	Yao Teng,Mingshu Pang,Jianyong Huang,et al. Mechanical Characterization of Cancer Cells in Epithelial-mesenchymal Transition Using an Electrodeformation-based Microchip, Mechanical Characterization of Cancer Cells in Epithelial-mesenchymal Transition Using an Electrodeformation-based Microchip[C]. 见:.