Long non-coding RNA Linc-RAM enhances myogenic differentiation by   interacting with MyoD

doi:10.1038/ncomms14016

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	Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD
	Yu, Xiaohua ; Zhang, Yong ; Li, Tingting ; Ma, Zhao ; Jia, Haixue ; Chen, Qian ; Zhao, Yixia ; Zhai, Lili ; Zhong, Ran ; Li, Changyin ; Zou, Xiaoting ; Meng, Jiao ; Chen, Antony K. ; Puri, Pier Lorenzo ; Chen, Meihong ; Zhu, Dahai
刊名	NATURE COMMUNICATIONS
	2017
关键词	SKELETAL-MUSCLE DIFFERENTIATION CHROMATIN REMODELING COMPLEXES CELL-DIFFERENTIATION DNA-BINDING SEQ DATA EXPRESSION LOCI TRANSCRIPTION COACTIVATOR CIRCUITRY
DOI	10.1038/ncomms14016
英文摘要	Long non-coding RNAs (lncRNAs) are important regulators of diverse biological processes. Here we report on functional identification and characterization of a novel long intergenic non-coding RNA with MyoD-regulated and skeletal muscle-restricted expression that promotes the activation of the myogenic program, and is therefore termed Linc-RAM (Linc-RNA Activator of Myogenesis). Linc-RAM is transcribed from an intergenic region of myogenic cells and its expression is upregulated during myogenesis. Notably, in vivo functional studies show that Linc-RAM knockout mice display impaired muscle regeneration due to the differentiation defect of satellite cells. Mechanistically, Linc-RAM regulates expression of myogenic genes by directly binding MyoD, which in turn promotes the assembly of the MyoD-Baf60c-Brg1 complex on the regulatory elements of target genes. Collectively, our findings reveal the functional role and molecular mechanism of a lineage-specific Linc-RAM as a regulatory lncRNA required for tissues-specific chromatin remodelling and gene expression.; National Basic Research Program of China [2016YFA0100703, 2014CB964703, 2011CBA01104]; CAMS Initiative for Innovative Medicine [2016-I2M-1-017]; National Natural Science Foundation of China [31471377, 91540206]; SCI(E); ARTICLE; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/475675]
专题	工学院
推荐引用方式 GB/T 7714	Yu, Xiaohua,Zhang, Yong,Li, Tingting,et al. Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD[J]. NATURE COMMUNICATIONS,2017.
APA	Yu, Xiaohua.,Zhang, Yong.,Li, Tingting.,Ma, Zhao.,Jia, Haixue.,...&Zhu, Dahai.(2017).Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD.NATURE COMMUNICATIONS.
MLA	Yu, Xiaohua,et al."Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD".NATURE COMMUNICATIONS (2017).