Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a   Novel Theranostic Nanomedicine for Breast Cancer

doi:10.1166/jbn.2016.2022

CORC > 北京大学 > 工学院

	Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer
	Zhang, Qian ; Du, Yang ; Jing, Lijia ; Liang, Xiaolong ; Li, Yaqian ; Li, Xiaofeng ; Dai, Zhifei ; Tian, Jie
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2016
关键词	Endostar Poly Lactic Acid (PLA) Zoledronic Acid (ZA) Breast Cancer Nanoparticle Molecular Imaging TUMOR-ASSOCIATED MACROPHAGES RECOMBINANT HUMAN ENDOSTATIN BIODEGRADABLE NANOPARTICLES DRUG-DELIVERY PROGRESSION METASTASIS THERAPY PHARMACOKINETICS ANGIOGENESIS CELLS
DOI	10.1166/jbn.2016.2022
英文摘要	Endostar, a novel recombinant human endostatin, has been proven to inhibit tumor angiogenesis and is utilized as an anticancer drug. While free drugs can display limited efficacy, nanoscaled anticancer drugs have been fabricated and proven to possess superior therapeutic effects. Poly(lactic acid) (PLA) is a FDA-approved biomaterial displaying excellent biocompatibility and low toxicity. In this study, Endostar-loaded PLA nanoparticles (EPNPs) were first prepared, and a near-infrared (NIR) dye, IRDye 800CW, was conjugated to the surface for detecting nanoparticle biodistribution through fluorescence molecular imaging (FMI) using an orthotopic breast tumor mouse model. The antitumor efficacy of EPNPs was examined using bioluminescence imaging (BLI) and immunohistology. To further improve the antitumor effects, we combined EPNPs with zoledronic acid monohydrate (ZA), which is known to decrease the tumor-associated macrophages (TAM) and inhibit tumor progression. We found that EPNPs decreased human umbilical vein endothelial cell (HUVEC) viability by inhibiting tumor growth gene expression more significantly than free Endostar in vitro. In vivo, EPNPs displayed better tumor growth inhibitory effects compared with free Endostar, and the combination of EPNPs with ZA exhibited more significant antitumor effects. As confirmed by CD31 and CD11b immunohistochemistry, the combination of EPNPs and ZA showed synergistic effects in reducing tumor angiogenesis and TAM accumulation in tumor regions. Taken together, this study presents a novel and effective form of nanoscaled Endostar for the treatment of breast cancer that displays synergistic antitumor effects in combination with ZA.; Program of the National Basic Research and Development Program of China (973) [2011CB707702, 2014CB748600]; National Natural Science Foundation of China [81090272, 81227901]; National Key Technology Support Program [2012BAI23B06]; State Key laboratory of Management and Control for Complex Systems [Y3S9021F30]; SCI(E); EI; ARTICLE; zhifei.dai@pku.edu.cn; tian@ieee.org; 3; 491-502; 12
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/437575]
专题	工学院
推荐引用方式 GB/T 7714	Zhang, Qian,Du, Yang,Jing, Lijia,et al. Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2016.
APA	Zhang, Qian.,Du, Yang.,Jing, Lijia.,Liang, Xiaolong.,Li, Yaqian.,...&Tian, Jie.(2016).Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY.
MLA	Zhang, Qian,et al."Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2016).