Growth, ageing and scaling laws of coronary arterial trees

doi:10.1098/rsif.2015.0830

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	Growth, ageing and scaling laws of coronary arterial trees
	Chen, Xi ; Niu, Pei ; Niu, Xiaolong ; Shen, Wenzeng ; Duan, Fei ; Ding, Liang ; Wei, Xiliang ; Gong, Yanjun ; Huo, Yong ; Kassab, Ghassan S. ; Tan, Wenchang ; Huo, Yunlong
刊名	JOURNAL OF THE ROYAL SOCIETY INTERFACE
	2015
关键词	arterial tree scaling law growth and ageing VASCULAR TREE BLOOD-FLOW BODY-SIZE MICRO-CT METABOLISM MORPHOMETRY NETWORKS DISEASE TEMPERATURE DISTAL
DOI	10.1098/rsif.2015.0830
英文摘要	Despite the well-known design principles of vascular systems, it is unclear whether the vascular arterial tree obeys some scaling constraints during normal growth and ageing in a given species. Based on the micro-computed tomography measurements of coronary arterial trees in mice at different ages (one week to more than eight months), we show a constant exponent of 3/4, but age-dependent scaling coefficients in a length-volume scaling law (L-c = Klength-volume . V-c(3/4); L-c is the crown length, V-c is the crown volume, Klength-volume is the age-dependent scaling coefficient) during normal growth and ageing. The constant 3/4 exponent represents the self-similar fractal-like branching pattern (i.e. basic mechanism to regulate the development of vascular trees within a species), whereas the age-dependent scaling coefficients characterize the structural growth or resorption of vascular trees during normal growth or ageing, respectively. This study enhances the understanding of age-associated changes in vascular structure and function.; Natural Science Foundation of China [11372010]; China MOST grant [2014DFG32740]; SCI(E); EI; PubMed; ARTICLE; tanwch@pku.edu.cn; yhuo@pku.edu.cn; 113; 20150830; 12
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435615]
专题	工学院
推荐引用方式 GB/T 7714	Chen, Xi,Niu, Pei,Niu, Xiaolong,et al. Growth, ageing and scaling laws of coronary arterial trees[J]. JOURNAL OF THE ROYAL SOCIETY INTERFACE,2015.
APA	Chen, Xi.,Niu, Pei.,Niu, Xiaolong.,Shen, Wenzeng.,Duan, Fei.,...&Huo, Yunlong.(2015).Growth, ageing and scaling laws of coronary arterial trees.JOURNAL OF THE ROYAL SOCIETY INTERFACE.
MLA	Chen, Xi,et al."Growth, ageing and scaling laws of coronary arterial trees".JOURNAL OF THE ROYAL SOCIETY INTERFACE (2015).