Design and development of novel MRI compatible zirconium-ruthenium   alloys with ultralow magnetic susceptibility

doi:10.1038/srep24414

CORC > 北京大学 > 工学院

	Design and development of novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility
	Li, H. F. ; Zhou, F. Y. ; Li, L. ; Zheng, Y. F.
刊名	SCIENTIFIC REPORTS
	2016
关键词	NEUROSURGICAL BIOMATERIALS BIOMEDICAL APPLICATIONS QUANTITATIVE-ANALYSIS BIOCOMPATIBILITY TI MICROSTRUCTURE FIBROBLASTS FIELDS NB RU
DOI	10.1038/srep24414
英文摘要	In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconiumruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are < 1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconiumruthenium alloys (1.25 x 10(-6) cm(3).g(-1)-1.29 x 10(-6) cm(3).g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, similar to 3.5 x 10(-6) cm(3) .g(-1), CP Ti and Ti-6Al-7Nb, similar to 3.0 x 10(-6) cm(3).g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, similar to 7.7 x 10(-6) cm(3).g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.; National Basic Research Program of China (973 Program) [2012CB619102]; National Science Fund for Distinguished Young Scholars [51225101]; National Natural Science Foundation of China [51431002, 31170909]; Beijing Municipal Science and Technology Project [Z141100002814008]; SCI(E); PubMed; ARTICLE; yfzheng@pku.edu.cn; 24414; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434075]
专题	工学院
推荐引用方式 GB/T 7714	Li, H. F.,Zhou, F. Y.,Li, L.,et al. Design and development of novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility[J]. SCIENTIFIC REPORTS,2016.
APA	Li, H. F.,Zhou, F. Y.,Li, L.,&Zheng, Y. F..(2016).Design and development of novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility.SCIENTIFIC REPORTS.
MLA	Li, H. F.,et al."Design and development of novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility".SCIENTIFIC REPORTS (2016).