Polydopamine-induced nanocomposite Ag/CaP coatings on the surface of   titania nanotubes for antibacterial and osteointegration functions

doi:10.1039/c5tb01597a

CORC > 北京大学 > 工学院

	Polydopamine-induced nanocomposite Ag/CaP coatings on the surface of titania nanotubes for antibacterial and osteointegration functions
	Li, Ming ; Liu, Qian ; Jia, Zhaojun ; Xu, Xuchen ; Shi, Yuying ; Cheng, Yan ; Zheng, Yufeng
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2015
关键词	HYDROXYAPATITE COATINGS IN-VITRO SILVER NANOPARTICLES TIO2 NANOTUBES ELECTROCHEMICAL DEPOSITION BIOLOGICAL-PROPERTIES OSTEOGENIC ACTIVITY DELIVERY-SYSTEM CELL-ADHESION IMPLANTS
DOI	10.1039/c5tb01597a
英文摘要	The initial implant-associated infections and post aseptic loosening are the major obstacles for the clinical applications of titanium-based dental and orthopedic implants. To tackle these issues, the implant surface is engineered to possess combined osteointegration and antibacterial properties. Therefore, a mussel-inspired novel nano silver/calcium phosphate (CaP) composite coating was prepared on anodized Ti, in the expectation of its surface maintaining preferable biological performance and possessing long-term antibacterial ability. This approach involves three steps: (i) the anodic oxidation of Ti to enable it to have a TiO2 nanotubular (TNT) surface structure, (ii) the self-polymerization of dopamine on TNT and the reduction of Ag and (iii) the modification of the Ag nanoparticles using polydopamine and further being immersed in SBF for the biomimetic mineralization of CaP. The surface morphology and microstructure of this novel coating was fully characterized. The Ag/CaP coatings displayed obvious antibacterial effects to S. aureus bacteria and relatively good in vitro cytocompatibility to MG63 cells. Compared with the pristine Ti, the cells cultured on the coated Ti showed enhanced ALP activities.; Project of Scientific and Technical Plan of Beijing [Z141100002814008]; National Natural Science Foundation of China [31370954]; State Key Laboratory of Bioelectronics Open Research Fund of China (Chien-Shiung Wu Laboratory); SCI(E); EI; ARTICLE; chengyan@pku.edu.cn; 45; 8796-8805; 3
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/424815]
专题	工学院
推荐引用方式 GB/T 7714	Li, Ming,Liu, Qian,Jia, Zhaojun,et al. Polydopamine-induced nanocomposite Ag/CaP coatings on the surface of titania nanotubes for antibacterial and osteointegration functions[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015.
APA	Li, Ming.,Liu, Qian.,Jia, Zhaojun.,Xu, Xuchen.,Shi, Yuying.,...&Zheng, Yufeng.(2015).Polydopamine-induced nanocomposite Ag/CaP coatings on the surface of titania nanotubes for antibacterial and osteointegration functions.JOURNAL OF MATERIALS CHEMISTRY B.
MLA	Li, Ming,et al."Polydopamine-induced nanocomposite Ag/CaP coatings on the surface of titania nanotubes for antibacterial and osteointegration functions".JOURNAL OF MATERIALS CHEMISTRY B (2015).