Predicting subsequent relapse by drug-related cue-induced brain   activation in heroin addiction: an event-related functional magnetic   resonance imaging study

doi:10.1111/adb.12182

CORC > 北京大学 > 工学院

	Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study
	Li, Qiang ; Li, Wei ; Wang, Hanyue ; Wang, Yarong ; Zhang, Yi ; Zhu, Jia ; Zheng, Ying ; Zhang, Dongsheng ; Wang, Lina ; Li, Yongbin ; Yan, Xuejiao ; Chang, Haifeng ; Fan, Min ; Li, Zhe ; Tian, Jie ; Gold, Mark S. ; Wang, Wei ; Liu, Yijun
刊名	ADDICTION BIOLOGY
	2015
关键词	Craving fMRI heroin addiction relapse METHADONE-MAINTENANCE TREATMENT NUCLEUS-ACCUMBENS DEPENDENT PATIENTS SMOKING-CESSATION COCAINE ADDICTION PREFRONTAL CORTEX REWARD CIRCUITRY ABSTINENCE FMRI STIMULATION
DOI	10.1111/adb.12182
英文摘要	Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue-reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin-dependent individuals. However, whether the changes in cue-induced brain response were related to relapse was unknown. In a prospective study, we recruited 49 heroin-dependent patients under methadone maintenance treatment, a gold standard treatment (average daily dose 41.8 +/- 16.0mg), and 20 healthy subjects to perform the heroin cue-reactivity task during fMRI. The patients' subjective craving was evaluated. They participated in a follow-up assessment for 3 months, during which heroin use was assessed and relapse was confirmed by self-reported relapse or urine toxicology. Differences between relapsers and non-relapsers were analyzed with respect to the results from heroin-cue responses. Compared with healthy subjects, relapsers and non-relapsers commonly demonstrated significantly increased brain responses during the processing of heroin cues in the mesolimbic system, prefrontal regions and visuospatial-attention regions. However, compared with non-relapsers, relapsers demonstrated significantly greater cue-induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. Although the cue-induced heroin craving was low in absolute measures, the change in craving positively correlated with the activation of the nucleus accumbens/subcallosal cortex among the patients. These findings suggest that in treatment-seeking heroin-dependent individuals, greater cue-induced craving and greater specific regional activations might be related to reward/craving and memory retrieval processes. These responses may predict relapse and represent important targets for the development of new treatment for heroin addiction.; National Natural Science Foundation of China [81201081, 81371532, 81071142, 81071143, 81271549, 61131003]; SCI(E); ARTICLE; tdwangw@126.com; 5; 968-978; 20
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/416897]
专题	工学院
推荐引用方式 GB/T 7714	Li, Qiang,Li, Wei,Wang, Hanyue,et al. Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study[J]. ADDICTION BIOLOGY,2015.
APA	Li, Qiang.,Li, Wei.,Wang, Hanyue.,Wang, Yarong.,Zhang, Yi.,...&Liu, Yijun.(2015).Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study.ADDICTION BIOLOGY.
MLA	Li, Qiang,et al."Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study".ADDICTION BIOLOGY (2015).